Platelet-derived Growth Factor B Chain And Vascular Endothelial Growth Factor Expression In Human Glioma And Its Clinical Significance

To evaluate the relationship between the expression of platelet -derived growth factor ( PDGF) B chain and vascular endothelial growth factor ( VEGF) in human glioma and the clinical pathological parameters such as pathological gradation, size, recurrence and prognosis.MethodApplying SABC immunohistochemical technique, we performed examination and statistical research on the expression in 33 cases of human glioma and 5 cases of normal brain tissue. The 33 cases of glioma graded according to WHO 1993 criteria. 13(39. 3% ) of 33 cases was astrocytoma. 11 (33. 3% ) of 33 cases was anaplastic astrocytoma. 9 (27.3%) of 33 cases was glioblastoma multiform.ResultIn this study, 28 appeared positive in the expression of PDGFBB in human glioma, and the positive rate was 84. 8%. We also observed the expression of PDGF in normal brain tissue, and the positive rate was 20%. VEGF expressed in glioma only, the positive rate being 81.8%, and no expression was observed in normal brain tissue. There was obvious difference in the expression of PDGFBB and VEGFbetween glioma and normal brain tissue ( P < 0. 01). There was also obvious difference between tumor pathological gradations and the positive expression of PDGFBB and VEGF ( P < 0. 01). Its positive expression increased with elevation of pathological gradation. There was no obvious difference between other clinical parameters such as, size, recurrence , prognosis and the expression of PDGFBB in glioma, however , the statistical difference in positive expression of VEGF between good and bad prognosis assessment was observed (p <0. 05). There was positive correlation between the expression of PDGFBB and VEGF (p<0.05).ConclusionGlioma can secrete PDGFBB and VEGF. There was relationship between the expression of PDGFBB and VEGF and pathological gradation of human glioma, and positive rate increased with elevation of pathological gradation. VEGF might relate with the prognosis of glioma. There was positive correlation between the positive expression of PDGFBB and VEGF in human glioma.