S100 Protein Expression In Renal Cell Carcinoma And Its Significance

Objective In order to search for a reliable clinical marker used to judge the invasion and malignant degree of renal cell carcinoma, we tried to explore the expression of S100 protein in the renal cell carcinoma, its clinical value and possible mechanism.Methods Immunohistochemical method was used in detecting the expressions of S100A1, S100B and P53 of mutational type in 36 RCC and 14 non-carcinoma renal tissues. The diversities of expressions of S100 protein between non-carcinoma and RCC tissues and among various pathological types and stages were closely studied. The relevances of S100A1, S100Band P53 were also analyzed to explore their possible mechanisms.Results 11 were negative staining and 3 were positive staining in S100A1 in 14 non-carcinoma tissues.5 were negative staining and 9 were positive staining in S100B in 14 non-carcinoma tissues. And negative staining was found in P53 in all 14 non-carcinoma tissues. The numbers of negative expression, faint staining, positive staining and strong staining in S100A1 in 36 RCC were 10,5,9 and 12 respectively. The numbers of the same sort in SIOOB were 23,5,5,3 and the numbers for P53 were 25,6,4 and 1 respectively. The expressions of S100A1 and P53 in RCC tissues were higher than non-carcinoma ones (P<0.05) .There were conspicuous diversities in the expressions of S100A1 among the RCC of various pathological types (PO.05) ,and the expression of S100A1 in high invasive type was higher than its low invasive partner. The high expression of SI00A1 correlated with increasing stage of RCC (PO.01 ) .There was not significant correlation between P53 of mutational type and SI00A1 or SIOOB (P?.05) .Conclusionsl.The expression of S100A1 was low in non-carcinoma tissues and was increased in RCC.2.S100A1 may be a useful marker in judging degree of malignance of RCC.IV3.S100A1 may be a new tumor marker in predicting the invasion of RCC.4.The functioning mechanism of SI00A1 was probably irrelevant to the mutation of P53 in RCC, and it might work through other various paths.