| Pediatric Bronchial Asthmas is the common allergic disease of respiratory tract. The incidence rate and death rate of Pediatric Bronchial Asthma is increased recently, and caused the worldwide attention. Most of the doctors believe that the high reactivity of the airway is the main trait of asthma, and the main pathological basis of the high reactivity of the airway is related to the inflammation of respiratory tract. Complicated etiology of the disease is affected by the factor of heredity and environment. Scholars suggest the different themry, such as the themry of inflammation of airway, unbalance of nerve-receptor, the unbalance of immunity, the themry of gastroesophageal reflux. The therapy of anti-inflammation is the common prevention of the infant asthma, and inhalation is popular treatment with infant asthma all around the world, doctors also developed some new medicines for the patients. The drugs of the asthma are divided into three parts: anti-inflammatory antiasthma medicine; anti-hypersensitive antiasthma medicines; the medicine for bronchiectasis.The etiology and pathology of the disease is that asthma is developed by the external evils because of the usual basis, the congenital deficiency, and the deficiency of lung, spleen, and kidney according to the theory of TCM. The main pathology is the blockage of Qi due to the stagnation of phlegm. Different stage, different treatment. Attacking page treated with eliminating of the evils, the remission stage treated with invigorate vital qi and consolidated the root. Some physicians believe that the combination of differentiating syndrome and disease, the complicated attacking and invigorating methods is effective, which can prevent the concurrence of the disease.Prescription I for asthma is based on the professor Li Bingnan?s experienced prescription, the main etiology and pathology of the disease isattacking of external evils, the complication of cold and heat in nature, and the combination of deficiency and excess. The prescription has got the effect of clearing away the exterior wind-cold and interior heat, tonifying qi and blood, dispersing qi and calming asthma. The main range of the application include slight and middle acute episode of asthma in infants.This research mainly focus on the clinical effect of Prescription I for asthma through the experience on the clinic and laboratory and try to find out the mechanism of the infant asthma.During clinical study, we divide the acute episode in slight and middle degree of 60 infant patients into TCM treatment group and aminophylline group for one week, and the 10 normal groups. Results show that Prescription I for asthma has got the same effect as aminophylline, the same effect of antiasthma,dispelling phlegm, cough-stopping, and the effect of dispelling phlegm is better than aminophylline?s. there is no significance comparing the ratio of cAMP cAMP/cGMP in plasma of infants after treatment. It indicated the Prescription I for asthma could improve the ration of cAMP/cGMP of infant asthma.Checking cAMP, cGMP through the methods of radio-immunity based on the duplication of the allergic asthma in Guinea pig using the 10% ovalbumin fluids and observing the pathomorphology changes of the Guinea pig lung tissues under the microscop and electron microscop. The results showed that the ratio of cAMP, cAMPkGMP of Guinea pigs in plasma is lowered down, and cGMP is increased before treatment, indicates the main etiology is related to the ration of cAMP/cGMP. The ratio cAMP, cAMP/cGMP is increased between two groups, and there is no significant comparing two groups, there is obvious significant of the two groups before and after treatment. After continuous 7 days?treatment, dissepiments of blood capillary in lung is relieved and the hyperplasia of collagen is disappeared, which indicated the degree of inflammation intissiues of guinea pig lung. The results of laboratory indicated the prescription could increased the ration of cAMP/cGMP, and relived the inflammatory degree of guinea... |
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