The Research Of The Predicted Factors For Asthma In Children With Wheezing

Objective: To explore the predicted factors of asthma in children under 5 years old with wheezing. Methods: Clinical data from 223 patients with wheezing were collected from Sep.2008 to Mar.2009. the data of those cases were collected by clinic service and telephone follow-up in post-discharge for 1 to 1.5 years. The independent effect of risk factors was obtained by Logistic regression analysis. Results: Eighty-six cases of 223(38.6%) children with wheezing developed into asthma. There were significant differences between asthma and non-asthma group in eczema, allergic rhinitis, food sensitization, family history of atopy/asthma, exercise induced wheezing, eosinophilia, recurrent lower respiratory tract infection(LRTI),serum total immunoglobulin E(IgE) and serum eosinophilic cationic protion(ECP)(P_eczema)=0.006, P_{allergic rhinitis})=0.000, P_{food sensitization})=0.012, P_{family history of atopy/asthma})=0.000, P_{exercise induced wheeze})=0.000, P_{recurrent LRTI}=0.000, P_eosinophilia=0.015, PIgE(+)及ECP(+))=0.000). The factors that contribute to the risk of asthma onset were eczema, allergic rhinitis, family history of atopy/asthma, exercise induced wheeze, recurrent LRTI, eosinophilia, IgE and ECP[OR(95%CI)_eczema =2.201(1.021-4.742), P)=0.044; OR(95%CI)_{allergic rhinitis}=3.140(1.462-6.740), P)=0.003; OR(95%CI)_{family history of atopy/asthma}=1.886(1.004-3.542), P)=0.048; OR(95%CI)_{exercise induced wheeze}=11.342(4.611-27.900), P)=0.000; OR(95%CI)_eosinophilia=7.378(2.115-25.750), P)=0.002; OR(95%CI)_{recurrent LRTI}=25.902(9.799-29.465), P=0.000; OR(95%CI)_{IgE(+)及ECP(+)}=9.204(1.487-25.231), P)=0.012; (P<0.05)] Conclusions: We used the factors of eczema, allergic rhinitis, family history of atopy/asthma, exercise induced wheeze, eosinophilia, recurrent LRTI, IgE and ECP₍to predict the likelihood of future asthma in children under 5 years old with wheezing.