| Object:There has been a rising trend of adolescents obesity in the last few years. Studies have suggested that childhood obesity will lead a"estrogen/testosterone rise", and even accompanied by gonadal abnormalities. Obesity male children and adolescents always have a increase on the rate of estradiol and testosterone in male obese children and adolescents. This study look through the period while puberty start to make a tentative research on the rate of estradiol and testosterone in male obese children and adolescents. The research discussed the hormone and growth difference between obesity male children and adolescents and normal ones, try to figure out the potential connection between obese and sex hormone during this age class.Methods:We choose 1059-12 year-old male subjects. Use their bone age to group them as prepubertal and in puberty, while define their BMI in to three subjects as "control subjects", "overweight subjects"and"obese subjects". Test their serum testosterone and estradiol, use Mann-Whitney Test to compare the testosterone and estradiol level and E2/T between obese subjects and control subjects.Results:(1) The 34.6% subjects reached puberty in obese subjects, while in control subjects is 34.6%. The bone age of obese subjects was significantly higher than control subjects. (2) Obese subjects have significantly higher testosterone and estradiol Mean Rank than control subjects. (3) Obese subjects showed a lower trend on E2/T Mean Rank than control subjects.Conclusions:(1) 9-12 year-old obese male children and adolescents have higher level of growth and development than normal ones. (2) 9-12 year-old obese male children and adolescents have higher estradiol and testosterone level than non-obese ones, this trend doesn't change much after they achieve puberty. (3) 9-12 year-old obese and non-obese male children and adolescents have no significant difference on the rate of estradiol and testosterone. |
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