Design Of Qingfei Xiaocuo Granules

Acne is the inflammatory disease of sebaceous follicles,and located primarily on the face, back and chest,where there are more sebaceous glands.Acne is common in clinic,which impacts people's health,work and lives.Developing the medicine curing acne will have social and economical returns.The western medicine of treating ance includes hormone and antibiotic medicine.The effect and side effect coexistent.Qingfei Xiaocuo granule is a kind of oral preparation composed of Traditional Chinese Medicine(TCM).It developed from effective prescription of TCM after properly disposed according to pharmacological and clinical practices.The granule is prepared by extracts from nine kinds of TCM.The preparation is organized reasonable and used to cure ance.The main research contents are as follows.A.The preparation procedure The preliminary extraction technology was chosen by pharmacodynamic screening test of four different extract in mice inflammatory model. Orthogonal test was employed for selecting the optimum of extraction technology by the indexes of the contests of tanshinoneâ…¡A and lithospermate B of the Radix salviae miltiorrhizae and Fritillaria thunbergii Miq after studying the optimum alcohol concentration.Orthogonal test was also employed to select optical extraction technology of the Scutellaria baicalensis Georgi and other herbs with dregs of the Radix salviae miltiorrhizae and Fritillaria thnnbergii Miq applying comprehensive score by the indexes of the contests of baicalin,paeoniflorin,ratio of water extract immersing paste and n-butanol extracting.And the contests of baicalin and paeoniflorin were also used to investigate the purification technology of water extraction.The concentrated technology of ethanol extraction was by the contests of tanshinoneâ…¡A,lithospermate B,baicalin and paeoniflorin.B.Forming procedure The granule was prepared by one-step palletizing.C.Quality standard The medical materials contained in Qingfei Xiaocuo granule was identified by TLC;The quality identification by TLC was specific,having a good separation and a clear spot in each thin layer plate.The content of baicalin in this preparation was determined by HPLC in the study of quality standard.The experimental results suggest that their linearity,precision, reproducibility,recovery are all satisfactory.The content of baicalin was no less than 20mg/g.D.The stability research The preparation character outward appearance,the load difference,the disintegration time limit,the moisture content determination,the microorganism limit,the qualitative distinction,the content determination item should be testified by sample preserved at room temperature.The test had been continuous carried out on for 3 months.The results didn't obviously change;It shows that the preparation was stable in the storage time,the stability was good.E.Pharmacodynamic Study Pharmacodynamie test showed that Qingfei Xiaocuo granule has the effect of reducing sebaceous patches,lowering T levels and improving E2 levels of Golden Hamster.The results show that the preparation procedure of Qingfei Xiaocuo is reasonable in technics,controllable in quality,good in stability,exat in effect.