The Design And Synthesis Of New Oxazole Ring Functional Groups Of Carboxypeptidase A Inhibitor

On the basis of the active site topology and enzymic catalytic mechanism of carboxypeptidase-A(CPA),2-benzyl-3-(2-oxo-2,3-dihydrooxazol-5-yl)propanoic acid and 2-benzyl-4-oxo-5-(pyridine-1-yl)pentanoate was designed as a novel type of inactivator. In the designing, the unique property of the oxazolone heterocycle was exploited as a latent inactivating species, the inhibitor were synthesized from succinic anhydride.The reduction of Δ⁷-6-keto-ergostane with Na₂S₂O₄ in the presence of a phase transfer catalyst & Li in the presence liquid NH₃ & Pd/C is performed and the effect of experimental conditions is discussed.