| Objective To comprehensively understand the development and evolution of the concept, relevant diseases and diagnostic features of blood stasis syndrome, and provide a theoretical basis for formulating and improving modern diagnostic criteria of blood stasis syndrome. Analysis the differences and related reasons between ancient and modern diagnostic of blood stasis syndrome, and expects it has certain meaning and value to build an integrated multi-dimensional system of blood stasis syndrome related diseases, diagnosis and treatment.Methods By literature research method, arrange the blood stasis syndrome-related data from dozens of TCM literatures, from "Treatise on Exogenous Febrile Disease" of the Han Dynasty to the Qing Dynasty, mainly summarize and analysis the contents of the blood stasis syndrome diagnosis, and take the discipline structure of modern "Diagnostics of Traditional Chinese Medicine" as a research framework, make the contents of blood stasis syndrome diagnosis of successive dynasties compared with modern "Diagnostics of Traditional Chinese Medicine" and diagnostic criteria of blood stasis syndrome. By statistical methods, count the frequency of blood stasis syndrome related traditional Chinese medicine in "Treatise on Exogenous Febrile Disease" and "Synopsis of Golden Chamber", to prove and analyze the characteristics of blood stasis syndrome in the Han Dynasty and law of development of blood stasis syndrome.Results "Syndrome" as a TCM terminology, whose concept and meaning has been constantly researched and studied since its birth, and the research of the relevant "syndrome" and "symptom", and their relationship with "disease" has never stopped. Blood stasis syndrome is one of the common clinical syndromes of TCM, it is a general designation of a collection of clinical syndromes group caused by blood stasis. As early as the pre Qin period, our ancestors have recognized the pathogenicity of blood stasis, and created such as stone needle, moxibustion, dance, drugs, etc. to cure and relieve the diseases. The theory of blood stasis in TCM originated from Inner Canon of Huang di, Zhang Zhongjing formulated the apellation of "blood stasis" and made systematic analysis and explanation of blood stasis syndrome related diseases, symptoms, therapy and prescriptions. Physicians of later ancient further classified and unified the diseases of same syndrome, such as "Xue Zheng chaper" in "Yu Ji Wei Yi" and "Zhu Xue chapter" in "Zhang Shi Yi Tong". To the Qing Dynasty, Wang Qingren and Tang Rongchuan further enriched and completed the relevant content of blood stasis syndrome. All these promoted the development of blood stasis syndrome, and laid the foundation for the establishment of the concept of blood stasis syndrome in future generations.Conclusions From ancient times until today, the development of blood stasis syndrome exhibits the periodic characteristics, blood stasis disease location and related diseases continue to expand the range, the tendency of blood stasis treatment gradually becomes standardized and diversified, and the diagnosis is becoming increasingly objective and standardized.In terms of diagnostic evidence of blood stasis syndrome, modern diagnostic criteria of blood stasis syndrome is more objectivity, remove a series of subjective clinical symptoms which are difficult to perceive and collect, and add the contents of physical and chemical examination, it recognize microcirculatory index of human body caused by blood stasis syndrome like microcirculatory disturbance.The difference between ancient and modern diagnostic evidence is caused by two reasons. Firstly, in order to promote and clinical application, diagnostic evidence should be more objective. Secondly, owing to the development of physical and chemical examination of medical science and the combination of modern scientific research ideas and technologies with TCM research, it is able to understand the essence of blood stasis syndrome clearly and deeply and diagnose blood stasis syndrome accurately from multiple angles.Ancient and modern diagnostic evidence of blood stasis syndrome did not unified in many aspects, and the items in the latest domestic diagnostic criteria of blood stasis syndrome is inadequate. The disease location in modern diagnostic criteria is general and vague. Therefore, the future research direction of diagnostic criteria of blood stasis syndrome should be aimed at disease location separately, to make diagnostic criteria of blood stasis syndrome more detailed and specific, and to make it provided with clinical practicality futher. |