Clinical Study On Treatment Of Ulcerative Colitis With Severe Active Stage By Oral And Enema Combined With Western Medicine

Background:Ulcerative colitis is one of the difficult diseases of the digestive system diseases. Severe ulcerative colitis is a specific style of ulcerative colitis, and it attracts more and more attention for its treatment,such as extensive colonic mucosa lesions, acute onset, a lot of blood in the stool, complications in critical condition, and poor patient compliance. In recent years, Chinese medicine has achieved good results in the treatment of the disease.Because it has a variety of treatment methods, fewer adverse reactions, lasting effect and other advantages, Chinese medicine treatment has become an important means of preventing and treating the disease.Objective:Observing the qingchangwenzhong prescription’s effect of the severe ulcerative colitis patients, to provide a clinical basis for its widely use in clinical treatments.Methods:We retrospectively selected 41 cases of severe ulcerative colitis patients who had been received treatment in Beijing Dong Fang Hospital from May 2014 to February 2016. All data of patients were entered Excel spreadsheets, build databases. Efficacy of before and after treatment, including:traditional Chinese medicine syndrome, disease activity score and the like. Using SPSS20.0 statistical analysis software for statistical analysis, compare the syndrome scores, mucosal lesions score of before and after treatment.Results:(1) The study included 41 patients, including 22 males and 19 females, aged 18-65 years. Their mean age were 38.02 years,16 cases within 18-29 years,10 cases within 30-39 years,8 cases within 40-49 years,7 cases within 50-65 years. Duration of less than 1 year in 16 cases,1-5 years in 17 cases,6-10 years in 1 case, more than 10 years in 7 cases.36 patients recevived western medicine treatment for mesalazine,5 patients recevived mesalazine combined hormone.4 cases were initial onset,37 cases were chronic relapse. Clinical classification are full colonic.(2) Patients were evaluated by symptom scale,0 cases were clinically cured,3 cases were markedly,38 cases were effective,0 cases were ineffective, the total efficiency was 100%, suggesting Qingchangwenzhong oral prescription and clyster combined with western medicine can reduce the clinical symptoms of activity severe ulcerative colitis patients, with statistical significance (P<0.05)(3) After treatment, there were 11 patients have taken a colonoscopy. after 6 months of treatment a total of 11 patients were reviewed colonoscopy, which 11 patients were disease activity assessment, the results showed that the effective rate of 90.90%, suggesting that the oral and bowel temperature enema Combined with Western energy lowering of moderate to severe active ulcerative colitis disease activity, with statistical significance (P<0.05). The review of 11 cases of patients with mucosal lesions colonoscopy efficacy assessment show that there were significant differences in mucosal lesions improved compared with the former after treatment, suggesting Qingchangwenzhong oral prescription and clyster combined with western medicine can improve colonoscopy mucosal lesions, with statistical significance (P <0.05).(4)After 2 weeks of treatment, laboratory texts hemoglobin (Hb), albumin (ALB), erythrocyte sedimentation rate (ESR), platelet (PLT) and C-reactive protein (CRP), and compared to the previous pre-treatment of the indicators. The inflammatory markers CRP and ESR was declined, PLT was decreased, while the Hb and ALB were significantly increased.Conclusion:Qingchangwenzhong oral prescription and clyster combined with western medicine can reduce the clinical symptoms, reduce disease activity of SUC patients. It’s also good for mucosal repair, deserves further study.