Study On The Regulation Of MMP - 1 And PGE <2> In The Knee Joint Of Knee Osteoarthritis By Tonifying Kidney And Removing

Objectives:By observing the kidney dehumidification method to adjust the fluid of the patients with knee osteoarthritis joint MMP-1 and the effect of content of PGE-2, in order to make clear the clinical curative effect of the treatment of knee osteoarthritis, for kidney dehumidification method for the treatment of knee osteoarthritis clinical application to provide reliable basis of evidence-based medicine.Methods:This research adopts the prospective, randomized, controlled clinical trial method, wangjing hospital of traditional Chinese medicine academy of sciences joint of China into the clinic of 60 patients with knee osteoarthritis, according to random number table method is divided into experimental group and control group 30 cases each. Patients with oral kidney dehumidification method of traditional Chinese medicine preparation to avoid Fried grain and joint injection of sodium hyaluronate, the control group using only joint injection of sodium hyaluronate; During the course of 4 weeks, the experimental group and control group were performed quadriceps exercises as the foundation treatment. Respectively before and 4 weeks treatment （end） when selecting patients of MMP 1 and PGE2 content in joint fluid, WOMAC score and TCM syndrome score as observing indexes, to clear kidney dehumidification method used in the treatment of knee osteoarthritis clinical efficacy and safety.All the test data collected by SPSS 19.0 software for statistical analysis.Results:The test group before treatment of MMP-1 content in synovial fluid was （85.28+14.32） pg/ml, PGE2 content is （73.66±18.57） pg/ml, TCM syndrome score （13.27+1.36）, WOMAC score （101.1+5.33）; the experimental group after treatment the content of MMP-1 in synovial fluid was （48.52+10.07） PG/ml, the PGE 2 content is （62.21+17.62） pg/ml, TCM syndrome score （5.60+1.03）, WOMAC score （48.60+7.731）; the control group before treatment MMP-1 content in synovial fluid was （86.48+8.56） pg/ml, PGE₂ content is （74.63+12.32） pg/ml, TCM syndrome score （13.23+1.55）, WOMAC score （101.4+5.34）; the control group after treatment MMP-1 content in synovial fluid was （71.87+8.88） pg/ml, PGE₂ content is （61.45+11.52） pg/ml, TCM syndrome score （8.80+1.27）, WOMAC score （68.30+5.43）; the statistical analysis between the two groups before treatment, MMP-1 content, PGE₂ content in synovial fluid and TCM syndrome score WOMAC score, no significant difference, comparable between the two groups; compared with each other in terms of reducing the content of MMP-1 in the synovial fluid, the two groups have significant differences （P< 0.01）, the experimental group was significantly better than the control group, but in the aspect of reducing the content of PGE₂ in synovial fluid, no significant difference between the two groups （P>0.05）; in the improvement of TCM syndrome score, two groups have significant difference （P< 0.05）, namely the experimental group than the control group, but in improving WOMAC score, no significant difference between the two groups （P> 0.05）; two groups of Chinese medicine clinical symptoms observation results:30 cases in the experimental group, the total efficiency of 96.67%, of which 29 cases were effective,1 cases ineffective; 30 cases in the control group, the total effective rate was 93.33%, of which 28 Cases,2 cases were ineffective, which showed that the experimental group was superior to the control group in improving the curative effect of TCM syndrome.Conclusions:Two groups in the treatment of knee osteoarthritis with obvious curative effect, but in the experimental group, the overall effective rate was higher than that of the control group; in reducing in decreasing the content of synovial fluid in PGE 2 in serum and to improve the efficacy of WOMAC score, the test group and the control group no significant difference; but in reducing in reducing the content of MMP-1 in synovial fluid and to improve the efficacy of TCM syndrome score, in the experimental group was better than the control group.