| BackgroundAllergic and rhinitis asthma syndrome (CARAS) is refers to the simultaneous occurrence in nasal and airway allergic diseases, it include allergic rhinitis (AR) and bronchial asthma (BA).In the past, allergic rhinitis (AR) and bronchial asthma (BA) were often treated as two diseases.In recent years, researchers found that AR and BA have close relationship in the etiology and pathogenesis.In western medicine,the paintents with AR and BA were diagnosed as allergic rhinitis and asthma syndrome (CARAS) by WAO.The diagnostic criteria of CARAS with reference to the diagnosis of AR and BA.In treatment,through the combination therapy to improve the therapeutic effect, and reduce the waste of medical resources.At present there is no corresponding disease diagnosis in traditional Chinese medicine, but the research on CARAS in traditional Chinese medicine is gradually increasing.On the study of CARAS syndrome type distribution law, the literature report is less, and the sample size is not large. The study is using self-made standard, lack of scientific and standardized syndrome research method, so,it has not summed up the syndromes of this disease.PurposeIn this study, literature review, clinical syndromes and cluster analysis methods were used to explore the distribution of TCM syndromes in CARAS patients.To sum up the characteristics of TCM Syndromes of CARAS, and provide clinical evidence for TCM syndrome differentiation and treatment of CARAS.MethodThrough the literature research to develop the CARAS TCM syndrome questionnaire.The study subjects were patients with respiratory and ENT specialist in Dongzhimen hospital, and the patients were diagnosed as CARAS.To carry out clinical investigation on them.In Epidata to establish a database, data entry.To analysis data by SPSS 22 statistical software.Using data descriptive statistics, sample clustering analysis and other statistical methods to distrib law of TCM syndromes and the basic pattern of CARAS.ResultA total of 41 patients with CARAS were included in the study.Female patients (26 cases) were more than male patients (15 cases).The mean duration of BA was 73.41±84.901 months, of which 8 cases had onset,33 cases of chronic duration and 0 cases of stable period.The mean duration of AR was 107.46±72.304 months, of which 28 were seasonal and 13 were persistent. Clinical symptom of patient with wheezing, cough and sputum, chest tightness, nasal congestion, runny nose, sneezing as the main performance.The frequency proportion of several symptoms was above 60%.The symptoms of 41 patients were analyzed by Ward method in cluster analysis, the results were divided into 4 types of syndrome types.There were 6 cases in the first category, accounting for 14.6%of the total.The syndrome is wind phlegm obstruction lung, lung-kidney deficiency and blood stasis.A total of second cases,11 cases, accounting for 26.8%.The syndrome is wind-cold fettering the exterior, asthenia of pulmonosplenic qi.A total of third cases,13 cases, accounting for 31.7%,The syndrome is spleen-asthenia with excessive damp, Wind phlegm invading the lung. A total of fourth cases,11 cases, accounting for 26.8%,The syndrome is wind phlegm bundle table, Lung spleen and kidney deficiency.ConclusionOf the 41 CARAS patients in this study, women were more than men. The average age was 44.6+12.6 years old.Longer duration of the disease, the mean duration of BA was 73.41±84.901 months, and the mean duration of AR was 107.46±72.304 months.This simple description of allergic rhinitis or asthma without standardized treatment or loss of treatment, to the late development of CARAS easily. The incidence characteristics of the patients for long duration, easy to recurrent, refractory.Most of BA patients were in remission period,and most of AR patients were seasonal. The most obvious symptom of the clinical symptoms is wheezing, coughing, chest tightness, nasal congestion, runny nose, sneezing.After the above symptoms were clustered by the system, the following four types of syndrome types were obtained.The first syndrome is wind phlegm obstruction lung, lung-kidney deficiency and blood stasis.The second syndrome is wind-cold fettering the exterior, asthenia of pulmonosplenic qi.The third syndrome is spleen-asthenia with excessive damp, Wind phlegm invading the lung.The fourth syndrome is wind phlegm bundle table, Lung spleen and kidney deficiency.It can be found that the characteristics of the pathogenesis is virtual real standard.The deficiency of spleen and kidney organs related disorders and lung function, most common in lung and spleen deficiency or yang deficiency of spleen and kidney.It is mainly related to the standard of the wind and the pathogenic wind, and the wind phlegm invading the lung through the whole process of the disease.Because of the shorter research time, met the inclusion criteria were less, so only the exploratory analysis of a small sample.The next step will continue to expand the sample size of the syndrome, in order to better summarize the syndrome distribution law of the disease. |