Study Of Relationship Of Anticardiolipin Antibodies In Patients With Acute Cerebral Infarction

Objective: To study the functions of ACA in occurrence and developing of acute cerebral infarction,by analyzing those functions with relationships of clinical characteristic , imaging datas , SSS scores and NIHSS scores of acute cerebral infarction , to provide experimental evidence and methods for preventing and treating cerebral infarction.Methods: Selected 112 patients with acute cerebral infarction and 40 healthy persons for Comparison.1. Collected the clinical datas of 40 healthy persons for Comparison and patients with acute cerebral infarction on admission (general state of health:such as age and gender; risk factor: such as smoking,drinking,history of hypertensive disease,history of diabetes and hyperlipoidemia, courses of disease and conditions of treatment of diseases such as hypertensive disease and diabetes).2.Completed laboratory examination contents of patients with acute cerebral infarction(blood glucose,blood fat,CRP , fibrinogen and so on )and documents of encephalon MRI,color ultrasound of carotid artery,SSSscores,NIHSS scores,MMSE scores and Hamilton depression scale scores.3. Detected (by ELISA ) ACA level of healthy persons for Comparison as well as those of patients with acute cerebral infarction within 3 days and 1 month after therapy.4.Divided patients with acute cerebral infarction into male group and female group according to gender,less than 50 years'group and more than 50 years'group according to age, cerbral infarction of monofocality and mulifocality according to numbers of cerebral infarction focus displayed by encephalon MRI,group with carotid artery plaque and group without carotid artery plaque according to outcomes of carotid artery plaque by means of color ultrasound,the first occurrence group and recurrence group according to with ischemic cerebrovascular disease or not, intervention treatment group and non-intervention treatment group by means of double-blind and control study(Two groups have the same fundamental treatments but the intervention treatment group: aspirin for oral use ,100mg, once daily, for 4weeks).5.Analyzed relative characteristics of ACA and ischemic cerebrovascular disease, correlations between risk factors of ACA and other cerebrovascular disease, Contrasted and analyzed the variation of the level of ACA,CRP and so on between intervention treatment group and non-intervention treatment group of pretreatment and posttreatment.6.All datas were analyzed by use of SPSS16.0 for windows.Result1.The level of ACA of the female group were higher than those of male group with significant difference(sP<0.05), less than 50 years'group were higher than more than 50 years'group(P<0.05), cerbral infarction of mulifocality were higher than monofocality with significant differences(P<0.05), cerebral infarction group with carotid artery plaque were higher than group without carotid artery plaque with significant differences(P<0.05),the recurrence group were higher than the first occurrence group with significant differences(P<0.05).2. The level of ACA were positive correlated to total cholesterol,low-density lipoprotein,TRIG,Fbg and CRP(P<0.05).3.Logistic regression analysises were carried out with acute cerebral infarction or not as dependent variable and indices with significant differences of one way factor analysis as independent variable,as a result, hypertensive disease,hyperlipoidemia and ACA made sense.4.The level of ACA were positive correlated to SSSscores,NIHSS scores,MMSE scores and Hamilton depression scalescores according to Spearman rank correlation(P<0.05).5.The decreased level of ACA and CRP of intervention treatment group were higher than those of non-intervention treatment group between pretreatment and posttreatment with significant differences(P<0.05).Conclusions:1. The level of ACA was close related to cerebral infarction of young and middle ages as one of risk factors probably.2. .The level of ACA of acute cerebral infarction was related to recurrence of cerebral infarction and cerbral infarction of mulifocality3. The level of ACA of acute cerebral infarction was related to dementia and depression.