Portulaca Oleracea Decoction On Mouse Model Of Ulcerative Colitis Experimental Study Of Effect

Objective The research project, the water decoction of the UC with purslane intervene in mice and used western medicine Sulfasalazine enteric-coated tablets were compared, the general condition of mice, body weight, pathological colon mucosa, and cytokines on the local the regulation of inflammation, observed drugs and control drugs, and treatment of drug delivery methods on the observation of different indexes, look for the role of the target of Chinese medicine for the treatment of UC to find the theoretical basis of Chinese medicine, Chinese medicine treatment of UC, to establish new ideas and Methods.Methods Clean level male Kunming mouse 84, after the repurchase, the compatibility feeds for 3 days, draw an item at random 18 as the blank group, give drinks 3% glucosan sodium sulfate solution freely to other mice (DSS) 10 days, prepares the ulcerous colitis model, through the observation contrast mouse's general condition, the body weight change and the excrement occult blood experiment, and after starting to make the mold the 11th day, executes the blank mouse and model mouse each 6 separately, draws blood with the colon organization, through in the colon organization pathological section and the blood IL-4, IL-6, in the colon organization IL-8, the IL-10 examination, by makes to order the mold to be successful firmly; The surplus model mouse will divide into the model group, the willow tree nitrogen sulfidin sulfanilylpyridine intestines to dissolve the piece group stochastically again (western medicine group), the verdolaga water decoctum to fill the stomach group (stomach group), the verdolaga water decoctum sausage group (mesogaster group), the verdolaga water decoctum to fill the stomach union sausage group (stomach and intestines group), each group of 12, the blank group and the model group fill stomach physiological saline 1ml every day, the western medicine group fill stomach SASP every day suspension 1ml, the stomach group fills stomach verdolaga water decoctum 1ml every day, mesogaster group daily sausage verdolaga water decoctum 1ml, the stomach and intestines group fills the stomach, sausage verdolaga water decoctum each 1ml every day, altogetherFor medicine 14 days. Yu Geiyao elsewhere 7 days, 14 weather each component dies 6 mice, the method, the process before.Results Portulaca oleracea decoction on the general condition of UC mice, body weight, pathological colon mucosa recovery played a good role; in active UC and in remission, purslane water decoction and Retention of small IL-4 in mouse blood and colon tissue of IL-10 increased, and blood in the colon of IL-6 and IL-8 in the lower are better than western medicineSulfasalazine enteric-coated tablet group.Conclusion The Portulaca oleracea decoction fills the stomach union sausage to treat the UC model mouse, adjusted in the UC mouse blood and colon tissue to press between the inflammation factor and the anti-SARS factor obviously is not balanced, declined the tissue immunity reactive state, reduced the mucous membrane inflammation damage, these functions were possibly one of its treatment ulcerous colitis's mechanisms.