The Retrospective Research On The Cases Of Professor Zhou Zhongying Treating Asthma Based On Data Mining

[Objective] Based on the TCM theory and clinical practice specialized by Professor Zhou Zhongying who is one of the topmost masters of TCM,combined with modern advanced data mining technology and scientific testing methods,we study,heritage and develop the clinical experience and academic ideas accumulated by Professror Zhou Zhongying treating asthma in the past two decades,in order to enlighten our thinking and guide clinical with his unique syndrome differentiation style and the law of prescription drugs.[Methods] We collect the clinical asthma cases of professor Zhou Zhongying over the past 20 years and input them into the computer. All data are classified,counted,analised,changed into Word document and archived.According to inclusion criteria, exclusion criteria to screen, we get 477 cases of 87 patients and establish a database mining platform for professor Zhou Zhongying treating asthma.According to the multidimensional,multi-stage,dynamic characteristics of medical record information,we take advantagesof a multi-disciplinary,multi-directional,multi-index comprehensive study to establish the best data mining model for medical record and make a systemic interpretation of the corresponding laws of disease,syndrome,symptoms and prescription and drugs.The joint use of association rules and chi-square test increase the reliability of the results of data mining and is the new breakthroughs and development of data mining used in the collecting old Chinese experience.Finally we explore the syndrome differentiation thinking and law of prescription drugs which is based on the analysis of the data mining results and combined with clinical experience of Professor Zhou Zhongying.[Results] Through the analysis of 447 cases of 87 patients,we come to some conclusions. Pathological factors of asthma include sputum, heat, wind, stasis, cold, drink, dampness and dry.Pathogenesis is mainly related to retention of phlegm-heat in the lung,both deficiency of Qi and Yin,accumulation of lung-heat,wind-phlegm attracting the lung,accumulation of phlegm-heat,wind pathogen invading the upwards,phlegm-dampness invading the upwards,disease of the lung and stomach and both deficiency of the lung and kidney.There is corresponding direct and indirect correlations with symptoms,pathogenesis and drugs, particularly with syndrome-drugs and symptoms-drugs,such as retention of phlegm-heat in the lung syndrome combination with nanshashen,beishashe,huangqin,zhimu.The remaining cards are also found to have similar combination of drugs,such as both zhimu and tinglizi are usesd to treat phlegm.We find that Professor Zhou Zhongying not only focus on the random change in clinical, but also on the essential drugs and prescription[Conclusion] Through the study we find that Professor Zhou Zhongying stress the function of pathological factors in the syndrome differentiation.sputurm,feve,blood stasis and wind are embodied in asthma.Professor Zhou Zhongying emphasis on the view of "infering the cause and judge the syndrome"and"judging the pathogenesis and designing the therapeutic trial principle" among syptoms,pathogenesis and drugs in asthma,which has a important and far-reaching meaning in TCM theory and clinical.He proposes several syndrome differentiation ideas and methods,such as focusing on the impact of the interrelationship of the Zangfu-organs,stressing the use of promoting blood circulation drugs in the treatment of asthma,specificing the existence of the tendence of changing between syndrome.Prescripting drugs are rigorous,flexible and changeable, cangercao,lufengfan,danshen,taoren,nanshashen and beishashen are commonly used and characteristics, the comparative results. of data mining and analysis are similar with Professor Zhou Zhongying's linical prescription,which certain the ablility of analysing the old Chinese medicine experience with the data mining.