| ObjectiveTo investigate the effect of Chitosan oligosaccharide on acute and chronic gout as well as mechanisms in order to develop new natural drug to control gout.Methods1. After an acute gouty arthritis model of rat was established with monosodium urate crystal (MSU), animals were randomly divided into normal control group, model group, positive control group and three prevented groups(n=8). The effect of Chitosan oligosaccharide on ankle perimeters, leucocyte count and IL-1βtest of rats was observed.2. After a chronic gout model of rat was established with adenine and ethambutol, animals were randomly divided into normal control group, model group, positive control group and three prevented groups(n=8). The effect of Chitosan oligosaccharide on activity of XOD, level of UA, BUN and CRE as well as pathological changes of kidney was observed.Results1. An acute gouty arthritis model of rat could be induced by MSU. Chitosan oligochitosan exhibited inhibitive effect on swelling of ankle and increased leucocytes as well as decreasing IL-1βof model rats (P<0.01).2. A chronic gout model of rat was established with adenine and ethambutol. Chitosan oligochitosan could lower activity of XOD and decrease level of UA, BUN and CRE (P<0.01). Monosodium urate crystals, cellular infiltration and damage of kidney tubules were reduced in Chitosan oligochitosan groups.Conclusion1. Chitosan oligochitosan can inhibit the attack of acute gouty arthritis in rats.2. Chitosan oligochitosan can prevent chronic gout in the hyperuricemia model of rats. |
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