Study On The Correlation Between The Clinical Diagnosis And Laboratory Indexes Of Sertoli-cell-only Syndrome

Abjective To retrospectively anylaze the relevance of laboratory indexes of 94 out-patients diagnosised sertoli-cell-only syndrome and find out the reference of the diagnosis of sertol-cell-only syndrome.Methods A total of 94 out-patient, who were diagnosised sertol-cell-only syndrome (SCOS) by testicular biopsy in Peking university Shenzhen hospital from July 2000 to April 2010, were summaried for clinical data, including Johnsen evaluation criteria which is used to evaluate the function of sperm generation, semen volume, semen liquefaction time, sperm density, total sperm count, sperm viability, percentage of sperm with different motility(a levels, a+b levels),sexual hormone (such as FSH,LH,et al),seminal plasma biochemistry and chromosomal karyotype, to summarize the laboratory and diagnostic indexes and analyze their correlation, then discuss the feasibilty of recommending some of laboratory indexes as the diagnosis ofSCOS.Results There was no difference in semen volume and seme liquefaction time. Sperm density, total sperm count, sperm viability and percentage of sperm with different motility(a levels, a+b levels) all were 0, majority of patients received only a routine examination of semen. The sex hormone levels showed that FSH was significantly higher than normal. Seminal plasma biochemical examination showed that fructose and a-glucosidase were normal; there was no abnormal karyotype in chromosome examination. Only one cases of patients was found with AZF deletion, mainly in AZFd region and AZFc region deletion, accurately for the STS location sY152, sY239, sY242, sY254,sY255 common deletion; socring system fo testicular biopsies(Johnsen score) prompted focal SCOS patients with a higher proportion of spermatogenesis arrest at spermatocyte stage, whose Johnsen score mainly at four. Johnsen score and FSH, FSH/LH values showed a negative correlation.Conclusions In order to furtherly standardize the progress of diagnosis of SCOS:Three or more semen examinations showed azoospermia, high FSH hormone level, high FSH/LH level, bilateral testicular biopsy showed spermatogenic cells were significantly reduced or absent, leaving only steroli cells. All mentioned above can be used as the diagnostic reference of SCOS;More point of bilateral testicular biopsy was a need for the diagnosis of completive SCOS. Chromosomal karyotype and seminal plasma biochemistry can be recommended as the exclusion checks of SCOS.