The Relationship Between Arterial Elasticity And Oxidative Stress And Endothelial Function In Patients With Hypertension Co-existed With Type 2 Diabetes Mellitus

Aim: To study the relationship between brachial-ankle pulse wave velocity (baPWV) and serum malonyldialdehyde, superoxide dismutase (SOD) and nitric oxide (NO) in patients with Hypertension Co-existed with Type 2 Diabetes Mellitus, and to investigate the effects of oxidative stress and vascular endothelial function on the development of arteriosclerosis.Method: 168 patients were grouped into normal control( n = 40), hypertension( n = 70) and hypertension complicated with type 2 diabetes mellitus group( n = 58). The serum NO, malonyldialdehyde and SOD were measured by colorimetric method respectively, and baPWV were recorded by an automatic arterial stifness measurement device.Result: Compared with the control group, serum malonyldialdehyde , baPWV were significantly higher and SOD, NO was lower ( P < 0. 05) in the hypertension group and the hypertension complicated with type 2 diabetes mellitus group. Compared with the hypertension group, serum malonyldialdehyde, baPWV were significantly higher and SOD, NO was lower (P < 0. 05) in the hypertension complicated with type 2 diabetes mellitus group. Correlation analysis shows that baPWV was positively correlated with ages, systolic blood pressure, dilated blood pressure, cholesterol, fasting blood glucose ( FBG) , high-sensitivity C-reactive protein (hs-CRP), serum malonyldialdehyde ( r = 0. 418,0. 672,0. 469,0.179,0. 392,0. 277,0. 571,all P<0. 05) ,and was negatively correlated with serum SOD and NO( r = -0.438,-0.571,all P <0. 05). The analysis of multiple stepwise regression shows that baPWV was positively correlated with systolic blood pressure, malonyldialdehyde, FBG and ages.Conclusion: Arterial elasticity significantly decreased and was correlated with increase of oxidative stress and reduction of vascular endothelial function in patients with hypertension complicated with type 2 diabetes mellitus, suggesting that oxidative stress and endothelial function plays an important role in the development of arteriosclerosis.