The Relationship Between High-sensitivity C-reactive Protein And ApoB, ApoB/ApoA1 Ratio In General Population Of Chongqing

Objective High-sensitivity C-reactive protein (hsCRP) is a biomarker of cardiovascular disease (CVD), and it is the strongest predictor of cardiovascular events, but the trigger of inflammation is still unclear. Hypertension, diabetes and obesity associate with inflammation, moreover, in vitro and animal studies support a role of elevated levels of atherosclerotic lipoproteins in the activation of inflammation. Apolipoprotein B (ApoB) reflects atherogenic particle number. Therefore we hypothesized that ApoB and ApoB/ApoA1 ratio were the important causes for elevated hsCRP. The aim of our study was to assess whether there exit the association between ApoB and hsCRP, furthermore, to examine whether the association between ApoB and hsCRP was stronger than other traditional risk factors of CVD.Methods We studied 511 apparently healthy adults from the Luohuang Power Plant community in Chongqing urban area (average age 46.0±11.6 years, including 352 males, 159 females). Height,weight,waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum hsCRP, fasting plasma glucose (FPG), 2h-OGTT plasma glucose (2h-PG), fasting insulin (FIns), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1, ApoB were ?measured. Body mass index (BMI), fasting insulin resistant homestasis model assessment (HOMA-IR), cholesterol and apolipoprotein ratios were calculated according to equation. The association between hsCRP and variables was examined by Pearson correlation analysis and stepwise forward regression analysis.Results The hsCRP levels were categorized into quartiles from the lowest to the highest concentrations (Q1-Q4).We found that BMI, WC, SBP, DBP, HOMA-IR, FPG, 2h-PG, FIns, TG, LDL-C, ApoB, ApoB/ApoA1 ratio, TC/HDL ratio, LDL/HDL ratio raised along with level of hsCRP increased (p<0.01), and HDL-C, ApoA1 declined with hsCRP incresed (p<0.0001). Then, different lipids, lipoproteins and apolipoproteins were categorized into quartiles to compare the means of hsCRP. We found the means of hsCRP all have significant differences among these groups (p<0.01), except TC (p=0.194). Concentration of hsCRP increased with levels of TG, LDL-C, ApoB, ApoB/ApoA1 ratio, TC/HDL ratio, LDL/HDL ratio, decreased with levels of HDL-C and ApoA1 (p<0.01). Pearson correlation analysis demonstrated that hsCRP correlated positively with BMI, WC, blood pressure, glucose, TG, ApoB, ApoB/ApoA1 ratio, TC/HDL ratio, LDL/HDL ratio (p<0.01), and negatively correlated with HDL-C and ApoA1 (p<0.01). According to stepwise forward regression analysis, WC was the only one variable that entered into the regression formula, and demonstrated that the relationship between WC and hsCRP was stronger than other cardiovascular risk factors.Conclusions hsCRP correlates with ApoB , ApoB/ApoA1, and also obesity,blood pressure,insulin resistance, lipids and lipoproteins as well. The correlation between hsCRP and WC is stronger than other traditional risk factors in these subjects. WC is an independent predictor for hsCRP.