Study Of The Correlated Hepatotoxicity On 70 AIDS Patients That Followed Up With The HAART In Xinjiang Area

Objective:To investigate and analyse the correlated hepatotoxicity during the HAART therapy, to avord the liver function injure, provide the scientic evidence. Methods:the CD4+ T lymphocyte counts, lymphocyte count's change of 70 cases who followed up with the HAART; The effection of the liver function by different therapy time were comparead retrospectively; Comparing the different treatment effect to the liver enzyme; Comparing the virus hepatitis or TB infected cases with HIV/AIDS; Comparing the effection of the liver function in different sex; Comparing the effection of the liver function in different age and nationality. Results:CD4+ T lymphocyte counts were increased significantly in the third month.7th month after the treatment, CD4+ T lymphocytes steady grewn in six month; After the HAART the 70 AIDS patients appearanced different extent liver function injure, and the count of AST, ALT, GGT, ALP increased, Comparing with before therapy, the count of AST, ALT have increased; There were statistics significance of hepatic lesion in co-infection with viral hepatitis. There were no statistics significance of hepatic lesion in different sex and age and nationality. Conclusion:It is obviously improved that the CD4+ T lymphocytes were increased evidently than before therapy; After ARV the hepato-enzymology markers have increased at the first month and 12th month; There were hepatic lesion in co-infection with viral hepatitis, and other aspacts. There were no statistics significance of hepatic lesion in different sex.