L-arginine On Chronic Obstructive Pulmonary Disease (COPD) And Pulmonary Hypertension Therapy

Objective: To investigate the chronic obstructive pulmonary disease and pulmonary hypertension after L-arginine in patients with pulmonary arterial pressure after the intervention of changes in hemodynamics and arterial blood gas..Case and Methods: From income to live in our hospital and diagnosed as chronic obstructive pulmonary disease in patients with pulmonary hypertension were randomly selected 60 cases, both from August 2007 to November 2009 received during the hospital stay of patients diagnosed are in line with 1977, the nation's first two plays of chronic pulmonary heart disease meeting criteria established by echocardiography measured pulmonary artery systolic pressure in excess of the current clinical application of diagnostic criteria of pulmonary hypertension 40mmHg. Were randomly divided into control group and L-arginine treatment group, 30 patients in each control group were male and 18 cases, 12 females, aged 55-82 years old (63.8±7.2 years), L-arginine treatment group, 20 cases of male and female 10 patients, aged 54, a 85-year-old (63.7±8.8 years). Each group by gender, age difference was not statistically significant (P> 0.05). The two groups before treatment in patients with pulmonary artery systolic pressure by echocardiography test (PAP), left ventricular end-diastolic volume (LVEDV), ejection fraction (EF), according to measured stroke volume, heart rate, body surface area calculation of cardiac index ( CI): arterial blood gas analysis through the detection of Pa02, PaC02, Sa02, and PH value. Fasting blood 5ml, put it aside for 30 minutes at room temperature self-curing, with its 3,000 rpm speed centrifuge for 15 minutes, the serum detection of NO. In addition, another 30 healthy volunteers of the above indicators detected as normal controls. Medication after a week in the above-mentioned indicators were again detected, according to two drug treatment group before and after the blood flow dynamics and arterial blood gas changes and efficacy between the two treatment group comparisons, analysis of chronic obstructive pulmonary disease with pulmonary hypertension, the clinical application of L -Arg treatment effect and mechanism. SPSS10.0 analysis software uses statistical analysis, t test methods for analysis.Results:1. After treatment than those in the two groups before treatment significantly decreased PAP, significantly different (P <0.01); efficacy comparison between the two groups were significantly different (P <0.05).2. L-Arg group and the conventional therapy group after treatment between the two groups cardiac index (CI) compared with that before treatment both increased, but has yet to reach statistical significance. L-Arg group and routine treatment group and the control group and two L-Arg group and routine treatment group comparison between the two groups there was no significant statistical difference.3. During the two groups of patients with mean arterial blood pressure medication has been reduced, suspended after 10 hours the two drugs mean arterial pressure and drug use earlier, no significant change.4. Two groups of patients with arterial oxygen partial pressure significantly increased after treatment, statistically significant difference (P <0.05), showed no significant difference between the two groups; the two groups after treatment in patients with arterial oxygen saturation also increased significantly, statistically there is significant difference (P <0.05); between the two groups showed no significant difference; L-Arg group and routine treatment group before and after treatment between the two groups significantly decreased arterial partial pressure of carbon dioxide, statistically significant difference (P <0.05). Between the two groups showed no significant difference; L-Arg group and routine treatment group before and after treatment between the two groups no significant change in PH value.5. L-Arg group before and after treatment significantly increased NO statistically significant difference (P <0.05), medication one week after L-Arg group and routine treatment group significantly increased NO statistically significant difference (P <0.05).In short, the two groups after treatment Pa02 and Sa02 were significantly increased, but the PH value and PaC02 no significant changes. Tip L-arginine can reduce the pulmonary artery without causing changes in acid-base balance. L-arginine intervention significantly decreased pulmonary artery pressure before and after treatment, compared with the control group statistically significant difference between treatment group and control group, pulmonary arterial pressure was significantly higher than the normal group differences were statistically significant.Conclusion: L-arginine on pulmonary hypertension treatment is effective on hemodynamics and no significant effect on water quality balance for the clinical treatment of hypoxia-related pulmonary hypertension provides a possible means. L-arginine intervention significantly increased NO before and after treatment Tip of COPD patients with pulmonary hypertension to reduce pulmonary artery pressure mechanism for the increase in NO content in blood.