The Diagnosis And Treatment Of Gastrointestinal Stromal Tumor

Gastrointestinal stromal tumors (GIST), is the most common mesenchy- mal tumors of the digestive tract,which takes 1â„…-3â„…of all tumors in digestive tract. It consists of spindle cells and epithelioid cells.It arises anywhere from the esophagus to the anus in this tract, but most commonly from the stomach and small intestine. Mutations of the c-kit protoncogene and the platelet- derived growth factor receptor genes are key events in GIST pathogen esis.GIST lacks specific clinical manifestation.The main manifestations include alimentary tract hemorrhage, abdominal pain, abdominal mass and so forth. CD117 and CD34 are important markers in the diagnosis of GIST. Surgical resection is regarded as conventional method of treatment.At present, combination of surgery with targeted drugs is advocated, and improved prognosis has been observed by using such drugs in those patients who suffered from unresectabletumors, recurrence or metastasis. In recent years, the disease was paid more attention. The purpose of this paper is to review systemically the published data on clinical feature, Immunohisto- chemistry, differential diagnosis, therapy and prognosis of GIST.