The Study Of Color Doppler Flow Imaging With Thyroid-Associated Ophthalmopathy

Objectives:To study the hemodynamic characteristics of ophthalmic artery and central retinal artery in patients with thyroid-associated ophthalmopathy(TAO). And analyze the relevance between the blood flow parameters and the clinical characteristics.At last, discuss the different influence factors on tetinal blood supply of patients with TAO.Methods:(1) Use the U.S. company GE's Logic7 Color Doppler Ultrasound diagnostic apparatus, to detect the ophthalmic artery and central retinal artery on 49 TAO cases (ninety eyes) whose thyroid function is normal or stable over six months and 24 normal controls (48 eyes), simultaneously, record its spectrum and measure the peak systolic velocity (PSV), end diastolic velocity (EDV), resistance index (RI). (2) According to the spectral characteristics of the central retinal artery, the TAO group was divided into two groups, the spectrum interruption group that include 21 patients(40 eyes) and the spectrum without interruption group that include 28 patients (50 eyes).(3) Analysis:To analyze the differences among the blood flow parameters are significant.,and analyze the correlation between the blood flow parameters and the clinical characteristics (4)Statistical Methods:The non-parametric test was used to compare the independent samples; The 2×2 tables x2 was used to compare the ratio.Results:(1)The PSV and EDV in normal control group are higher than in TAO group,and the RI in normal group is lower than in TAO group,P<0.05.(2)The constituent ratio of the eyes whose CRA spectrum is interrupted is higher in TAO group than in normal control group, P<0.05.(3)There is no statistical significance of the OA PSV between spectrum interruption group and spectrum without interruption group,P>0.05;The CRA PSV in spectrum interruption group is lower than in spectrum without interruption group, P<0.05;The EDV of OA and CRA in spectrum interruption group is lower than in spectrum without interruption group, P<0.05; The RI of OA and CRA in spectrum interruption group is higher than in spectrum without interruption group, P<0.05.(4)Either the PSV or the EDV of OA and CRA in normal control are higher than in spectrum interruption group, P<0.05; The RI of OA and CRA in normal control are lower than in spectrum interruption group, P<0.05.(5)For the PSV of OA,there is no statistical significance between normal control group and spectrum without interruption group, P>0.05;The EDV of OA in normal control group is higher than in spectrum without interruption group, P<0.05; The RI of OA in normal control group is lower than in spectrum without interruption group, P< 0.05;The PSV and EDV of CRA in normal control group are higher than in spectrum without interruption group, P<0.05; There is no statistical significance of the CRA RI between two groups,P>0.05.(6)There is statistical significance for the differences of orbital pressure and exophthalmos between the spectrum interruption group and spectrum without interruption group; There is no statistical significance for the differences of the constituent ratio of enlarged extraocular muscle between the spectrum interruption group and spectrum without interruption group.(7)The PSV and EDV of OA tended to be negative correlated with exophthalmos, P<0.05; The EDV of CRA tended to be negative correlated with exophthalmos, P<0.05.(8)The RI of OA tended to be negative correlated with the EDV in TAO group, P<0.05; The RI of CRA tended to be negative correlated with the EDV in TAO group, P<0.05.Conclusions:(1)Under the situation of normal thyroid function,either the PSV or the EDV of OA and CRA in TAO patients is decreased compared with normal subjects,and the RI is higher than normal subjects,and the blood flow parameters are correlated with exophthalmos.(2) The ratio of the eyes whose CRA spectrum is interrupted is higher in TAO group than in normal control group.(3)In the TAO patients,the blood flow velocity of the eyes whose CRA spectrum is interrupted is lower than the eyes whose CRA spectrum is not interrupted,but the RI is higher than the eyes whose CRA spectrum is not interrupted.(4)The increase of orbital pressure of TAO patients leads to the change of the blood flow parameters,that is the CRA spectrum is interrupted and the OA spectrum becomes steep compared with the normal subjects.