CD83, CD1a And Ki-67 Expressions In Colorectal Carcinoma And Its Prognostic Significance

AIM:To explore the expressions of CD83, CDla, and Ki-67 in colorectal carcinoma and its prognostic significance. METHODS:Using immunohistochemistry and flow cytometry detected 60 cases of colorectal cancer CD83, CDla, and Ki-67 expression analysis of colorectal cancer with clinicopathological features and prognosis. RESULTS: Immunohistochemistry showed, CD83 and CDla expression in A phase and B phase colorectal cancer was significantly higher than C phase and D phase group(P<0.05); CD83 and CDla in the expression of≥5 years survival group was significantly higher than≤3 years of death group(P<0.05). Ki-67 expression in A phase and B phase colorectal cancer was significantly lower than C phase and D phase group(P<0.05); Ki-67 in the expression of≥5 years survival group was significantly lower than≤3 years of death group (P<0.05). Flow cytometry showed, CD83 expression in A phase and B phase colorectal cancer was higher than C phase and D phase group (t=2.916, P<0.05); CD1a expression in A phase and B phase colorectal cancer was higher than C phase and D phase group (t=2.747, P<0.05), CD1a in≥5-year survival group than those in the death group≤3 years (t=3.713, P<0.05); Ki-67 expression in A phase and B phase colorectal cancer was lower than C phase and D phase group (t=-2.775, P<0.05), Ki-67 in the expression of≥5 years survival group was lower than≤3 years of death group (t=3.713, P<0.05). CONCLUSION:CD83, CDla, and Ki-67 expression and Dukes staging and prognosis of colorectal cancer related to detection of colorectal cancer prognosis can be used as a reference indicator.