Effects Of Aerobic Exercise On Learning And Memory Of AD Model Rats And On The Related Nutrition Factors In Hippocampus

With the acceleration of population aging, Alzheimer's disease (AD) incidence rate was on the rise. It is worth to study the physical exercise and the promotion of exercise. Aβ1-42(Aβ42)is the main pathological signs in brain of AD.Aβ1-42 runs through the whole pathological process of AD by its formation, deposition and degradation. And it is the main cause of AD. Study found that Aβ1-42 can be decreased by training, which has a preventive effect on AD. The spatial learning ability in rats' hippocampus can be increased by appropriate training, which may be related to the acquisition of neurotrophic factor expression in the hippocampus and an increase in receptor density. The mechanism of exercise promoting neural plasticity may be due to the increase of BDNF and the receptor expression in the brain in the movements. The increase of BDNF caused the growth of brain nerve and the tolerance of brain and memory and learning ability.This study aimed to explore the mixed aerobic exercise on D-galactose-made model of the AD rats the impact of learning and memory ability. Discussing whether the exercise has the preventive effect or antagonism to AD and research the mechanisms of BDNF, IGF-1.And discuss the protective and anti-aging effects of neurotrophic factors, with a view to find a new breakthrough of prevention and treatment of AD in clinical by exercise training.16 purebred male Spargue-Dawley rats are divided into two groups:Controlled(C, n=8), Trained(T, n=8). All of rats are injected by D-galactose(120mg/kg·d) at 10am for 8 weeks.They swam on Monday, Wednesday and Friday. And they ran on Tuesday, Thursday and Saturday. After the mixed training for 8 weeks, all of the rats participate in the test of Morris maze. Then, inspecting the expression of BACElmRNA, BDNFmRNA and IGF-1mRNA by RT-PCR;inspecting the expression of Aβ1-42 by Western blot. The results are as follows:(1)According to the data of the place navigation and spatial probe test in Morris maze, we know that comparing with the controlled group,8 weeks aerobic training up regulated significantly the results in Morris maze.(2) Comparing with the controlled group,8 weeks aerobic training up regulated the expression of IGF-1mRNA(p<0.01);down regulated the expression of BACE1mRNA(p<0.05) in hippocampus.(3) Comparing with the controlled group,8 weeks aerobic training down regulated the expression of AP1-42 in hippocampus.Conclusion:1.8 weeks aerobic exercise training can improve the function of spatial learning and memory in AD model rats.2.8 weeks aerobic exercise training can down regulate the expression of BACE1mRNA. It proves that optimal exercise training maybe can put off the development of AD.3.8 weeks aerobic exercise training can up regulate the expression of IGF-1mRNA. It proves that optimal exercise training can improve the psychological health.4.8 weeks aerobic exercise training can down regulate the expression of Aβ1-42. It proves that optimal exercise training maybe can resist the development of AD.