The Clinical Significance Of Serum Adiponection Level In Patients With Inflammatory Bowel Disease

Objective: To compare serum adiponectin level in patients with inflammatory bowel disease ( IBD) and healthy controls, and to analyzs its correlation with disease activity and localization.Methods: Serum adiponectin level were measured in 35 IBD patients and in 19 healthy controls using commercially available enzyme-linked immunosorbent assays. Pearson correlation coefficient was used to analyze the correlation between serum adiponectin and disease activity(activity index and C-reactive protein),localization.Results: Serum adiponectin was significantly higher in CD and UC patients ( 12.44±6.44μg/ml and 16.81±11.60μg/ml ) than in healthy controls ( 5.02±3.59μg/ml ). Serum adiponectin level was correlated with its activity index ( Southerland's index ), but not correlated with C-reactive protein levels in ulcerative colitis patients. In Crohn's disease patients, serum level of adiponectin was not correlated with either C-reactive protein levels or the activity index. No association between serum adiponectin level and disease localization in both CD and UC patients was found.Conclusions: Serum level of adiponectin is increased in patients with IBD and the level of serum adiponectin is positively correlated with Southerland's index . Adiponectin may be correlated to pathogenesis and activity of IBD.