| Objective:To observe the clinical effects of Wujing Ointment in educing adverse reactions and initially explore its mechanism of action by treating the patients of Cancer of Colorectum attached to Asthenia of Spleen and Pathogenic damp with FOLFOX4. Methods:76 cases who meet the diagnosis standard of Cancer of Colorectum from our co-operation hospitals were domized into two groups (38 cases respectively):the control group which FOLFOX4 only was given and the treatment group used Wujing Ointment at the same time.,60g/d, three times a day.After one cycle,we surveied the quantity and the descenting rate of WBC,the quantity and the descenting rate of Hg,incidence rate of nausea and vomit,the changes of syndromes of TCM,Karnofsky scores,immunity and completed rate of chemotherapy.Results:the WBC quantity of two group decreased after chemotherapy, the descenting rate of WBC of the treatment group is lower than the control group, and the difference was significant statistically (P<0.05); The descenting rate of Hg of two groups and the degree has no statistical difference (P> 0.05). The syndromes of TCM of two groups all increased after chemotherapy (P< 0.05).and there was different statistically (P<0.05); The Karnofsky scores of two groups all increased after chemotherapy (P<0.05).and there was a statistical difference (P<0.05); The immunity function after chemotherapy were higher than the before,and the differences were significant statistically (P<0.05). The completed rate of chemotherapy of two groups was higher than 85%, and there was no different(P>0.05).Conclusion:1.Wujing Ointment can boost patients'immunity after FOLFOX4 and can elevate CD4,CD4/CD8,NK, and reduce CD8; Wujing Ointment can lower the descenting rate of WBC; Wujing Ointment can improve the patients'KPS.2. Wujing Ointment can improve the TCM clinical symptoms of asthenia of spleen and pathogenic damp due to chemotherapy and improve the patienrts'quality of life. |
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