Clinical Study Of Renal Function In Patients Undergoing Coronary Intervention

Objective:To observe the morbidity and the related risk factors of CIN of patients undergoing coronary angiography,and assess the accuracy of Scr and eGFR in diagnosing the CIN.Methods:131 cases undergoing coronary angiography hospitalized in our ward from Dec.2009 to Mar.2010 were enrolled, the nationality,gender age,drugs before coronary angiography were recorded. Scr was measured at any time 5 days before the angiography and 2 days after the angiography.131 cases were divided into two groups(CIN group and no-CIN group) by the increasing of Scr of 25%of the baseline at 48 hours after the angiography.eGFR was calculated by MDRD formula. Use kappa analysis to evaluate the accuracy of diagnosing CIN of increasing percentage of eGFR before and after the angiography. To observe the incidence of CIN among common patients,the han and uygur nationality and diabetes cases,and make a Logistic regression analysis of possible risk factors of CIN. Results: Scr* after the angiography significantly increased compared with that before the angiography in both CIN group and non-CIN group(P both<0.05).There was no significantly difference for Scr before angiography between the two groups, but for that after the angiography was; Scr after the angiography in eGFR before the angiography< 90ml/min group increased significantly compared with that before the angiography (P<0.05);There was no significantly difference for Scr both after and before the angiography in eGFR before the angiography>90ml/min group; Kappa analysis showed the accuracy of eGFR in diagnosing the CIN was completely uniform with that of Scr(k=1,P=0.000). The AUC of Scr and eGFR were 0.979 and 1 respectively (P<0.05). There was no significant difference for the prevalence of CIN between uygur nationality and han-nationality.There was no significant difference for CIN between the eGFR before the angiography< 90ml/min and the eGFR before the angiography>90ml/min groups. The morbidity of CIN of patients with diabetes was remarkably higher than that of patients without diabetes. Logistic multivariate analysis demonstrated the diabetes,age beyond 70 years,LVEF below 45%were both the independent risk factors of CIN. Conclusions:The prevalence of CIN in common cases was 6.1%. There was no statisticly difference for the incidence of han nationality and the uygur nationaoity.The morbidity of CIN of patients with diabetes was higher than that without diabetes. The diabetes,age beyond 70 years,LVEF below 45% were both the independent risk factors of CIN.