| In 1967, with the discovery and later clinical application of anti-tumor activity of cisplatin, the research on anti-tumor activity of metal coordination compounds had been attracting widely attention. People constantly design and compose organometallic complex compoumds with novel structures, expecting to obtain anticancer drugs with low-toxicity, high-efficiency, and high-selectivity after screening. Pydiyl carboxylate acid ligands with kinds of coordination groups can coordinate to several metal ions with various coordination modes, Therefore their coordination polymers have aroused much interest and become the focus of research.1. In this dissertation, 4-hydroxypyridine-2, 6-dicarboxylic acid was selected as the ligand. Based on the principle of crystallography, six new complexes of transition metal or lanthanide nitrates with novel structures were synthesized by hydrothermal method and obtained in the form of single crystals.(1)Nd(CAM)(H2O)3·H2O(2)Cd4(HCAM)4(H2O)8(3)La2(CAM)2(H2O)6(4)Sm(CAM)(H2O)3·H2O(5)Ce2(CAM)2(H2O)6(6)Mn4(CAM)3·H3OTheir structures have been analyzed by single-crystal X-ray diffraction, and briefly described. Both complex 1,4 and complex 3,5 are homeomorphy compounds, respectively.2. The complexes and ligand have been characterized by IR. Furthermore the IR have been employed to characterized the above compounds. Then fluorimetric analysis has been used to study on the complexes and ligand. Both the ligand and complexes 1,2,3,4 exhibit luminescence. 3. The inhibition of the complexes against K562 and HL60 cells was determined by MTT assay. The results showed that the concentrations of complexes were positively correlated with inhibitions against K562,HL60 cells. Only complex 2 showed certain extent of inhibition against both two cells. And complexes 1,6 showed inhibition against only HL60 cell. |
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