The Epidemiological Survey Of Quality Of Life In Patients With Thyroid Associated Ophthalmopathy

[Objective]: 1.Retrospectively analysis the 210 cases of the Thyroid-associated ophthalmopathy patients'clinical data to explore the Thyroid-associated ophthalmopathy'course prevalence, clinical features and disease factors. 2. Using the current internationally accepted Graves'Ophthalmolopathy Quality of Life questionnaire(QO-QOL) to evaluate the Thyroid-associated ophthalmopathy patients'quality of life,Then analysis of the quality of life in patients with thyroid-associated ophthalmopathy influential factors.3. Comparison the different of patients quality of life afer different treatments and smoking .[Method]: 1. Collected and retrospectively analyzed 210 patients (380 eyes) of thyroid-associated ophthalmopathy clinical data, to explore the Thyroid-associated ophthalmopathy'course prevalence, clinical features and disease factors. 2. Collected in 75 patients with the thyroid-associated ophthalmopathy and 75 cases normal control group.Application QO-QOL to compare the differences in quality of life ,analysis the factors caused reducing quality of life in the Thyroid-associated ophthalmopathy. 3. Comparison of 75 patients'changes in quality of life before and after treatment , Influence of smoking to the patints'quality of life. [Results]:1 . The Thyroid-associated ophthalmopathy occurred in 40-year-old middle-aged,and as age increases, increase the proportion of male patients; Thyroid-associated ophthalmopathy may be associated with abnormal thyroid function,and can be seen in patients with normal thyroid function, more common of associated with hyperthyroidism(69.0%). Euthyroid TAO mostly unilateral disease (71.4%),Thyroid dysfunction, mostly bilateral disease (94.0%). Upper eyelid retraction is the most common (67.6%) in eyelid symptoms;Exophthalmos mostly infemale patients, and the average age is younger; Diplopia mostly male patients,and the average older, and to more smokers, a large proportion of high intraocular pressure and high intraorbital pressure; the inferior rectus most common in the thickening rectus extraocular muscle. About 63.1% after I131 treatment occurred eye symptoms or aggravated eye symptoms . 95.6% patients with thyroid-associated ophthalmopathy appeared varying degrees of anxiety state. 2. Thyroid associated ophthalmopathy patient group and control group's quality of life scores were significantly different,and visual function and psychosocial scores in the thyroid-associated ophthalmopathy were all lower than the normal control group (P <0.001); Visual function scores in patients of different age groups with significant difference scores (P =0.02), Psychosocial scores among the three groups statistically significant difference (P =0.03), three age groups as the functional scores and psychosocial scores of the two statistical comparison between the two groups, found that less than 30 years of age group 30 to 50 age group as the functional scores and psychosocial score ,witch was no significant difference (0.06;0.07),the 50-year-older group's the functional scores and psychosocial scores were were statistically significant differences than the other two groups (0.01,0.02;0.008;0.005); There was no significant difference between visual function scores in patients of different gender (0.06), The social psychology of women scored significantly lower than men's, and the difference was statistically significant (0.008); different clinical symptoms of patients of visual function score was significant statistical difference (P =0.02), psychosocial scores among the three groups statistically significant difference (P =0.04), between the three different clinical presentations of visual function score and psychosocial scores between the two groups'statistical comparison showed : Exophthalmos and lid retraction group group score and visual function scores had no significant difference in social psychology scores (0.06,0.08), the diplopia group and the other two groups in visual function and psychosocial scores have significant statistical difference (0.001,0.03; 0.004,0.01); two groups of patients with eye disease rating score of visual function and no difference in social psychology (0.06,0.09).3. The thyroid-associated ophthalmopathy with a variety of in quality of life before and after surgical treatment, but the patients with corticosteroid therapy had no difference in the quality of life before and after treatment.[Conclusion]: 1. Clinical features of thyroid-associated ophthalmopathy has its own characteristics, it is important of early correct diagnosis and the rational analysis of disease outcome and prognosis of the disease. Patients should pay attention to changes in anxiety, Response to intervention in patients with psychological factors.,when treating of the thyroid -associated ophthalmopathy. 2. The quality of life in patients with thyroid-associated was significantly lower than the normal population. Therefore, GO can be considered as a serious chronic diseases , and there is an urgent need to carry out more in-depth studies to find more effective treatment methods to reduce the suffering of patients.The main factors of quality of life in patients with thyroid-associated ophthalmopathy are including age, gender, diplopia. 3. The current domestic surgical treatment of thyroid-associated ophthalmopathy improved the patients'quality of life . Before and after treatment with TAO-QOL scale assessment could be more accurate assessment of patients after treatment by the benefits of different situations, the clinical benefit for patients to develop personalized treatment plan.