| Overactive bladder (OAB) is a group of symptoms with urinary urgency, urinary frequency and urge urinary incontinence. Sometimes these symptoms appear alone, and sometimes appear in a way of combinational form. Benign prostatic hyperplasia (BPH), as the most commonly optimum disease in the elder men, results in urinary frequency, urinary urgency and dysuria. The operative way of treating BPH is transurethral resection of prostate (TURP), with keeping the catheter postoperate for 5 days. At that time, the patients may turn out the symptoms of desiring to urinate and paining in the hypogastrium, usually going with urine erupting around the catheter. In order to improve these symptoms, we use solifenacin succinate for the treatment.Objective To observe the clinical validity and security of solifenacin succinate, treating several symptoms (urinary urgency, urinary frequency and urge urinary incontinence) of OAB, which result from keeping catheter after the operation of transurethral electrocision of prostate. Methods Using the overactive bladder-assess (OABSS), 41 patients which suffered the several symptoms (urinary urgency, urinary frequency and urge urinary incontinence) of OAB, resulting from keeping catheter after the operation of transurethral electrocision of prostate, were collected. And their grades of OABSS and urinary urgency were marked, as called the baseline grade. These 41 patients were randomized to the treatment group and the matched group. This trial was carried on single-blindly, with one group taking oral solifenacin succinate(5mg), once daily with or without the food, the other nothing. All these 41 subjects on trial were observed, until we pulled out the catheter 5 days after the operation. The numerical values of the OABSS and urinary urgency grade when the trial began 3 and 5 days were recorded. We also observed the incidence of dry mouth, constipation, blurred vision and other adverse effects. After taking the medicine in the treatment group, the results of the liver function test and the renal function test were compared with what was tested before, and we watched whether they changed abnormally, or not. Using the statistical software of SPSS 15.0, we managed and analysised the result of the trial. First of all, the data of the test result was digested into the excel form, in order to carry on the statistical process conveniently later. Second, we tested the normality of all the experimental data in both the treatment group and the matched group, founding that most of these were not normality distribution, with the possible reason that the result of the trial was range value. Therefore, the Wilcoxon signed ranks test was carried on to compare the baseline OABSS grade, the baseline urinary urgency grade, the third day OABSS grade, the third day urinary urgency grade, the fifth day OABSS grade and the fifth day urinary urgency grade of one group with the other. If the P value was less than 0.001, then we thought the differences were statistical significance. Results All the subjects finished their trial, and no one broke down or quitted in the middle. Using the statistical software, we compared the baseline OABSS and urinary urgency values of the treatment group and the matched group, which turned out to be that the P values were 0.635 and 0.799 (P>0.001), meaning that this baseline data wasn't different statistically, and that the comparisons carried on below made sense, in order to let up the error. 3 days after taking (or not taking) solifenacin succinate, the Wilcoxon signed ranks test showed the results of the comparison between the OABSS grade and the urinary urgency grade of the treatment group and the matched group that both of the P values were 0.000 (P<0.001), meaning that the difference between the double experimental data was significant, which implied that having this medicine was good for treating the symptom. After taking this medicine for 5 days, OABSS whose the values of urinary urgency≤1, and the total≤2, as called the non OAB, accounted for the percentage of 95.2% in this group. What came up to the same condition of the matched group accounted for 2%. Using the Wilcoxon signed ranks test, we calculated the P values of the two group at this time, which were 0.000 (P< 0.001), showing that the difference was also significant, which meaned that solifenacin succinate treated the several symptoms (urinary urgency, urinary frequency and urge urinary incontinence) of OAB effectively. During the cure in the treatment group, there were only two subjects showing up dry mouth, one of whom had constipation. There were no other obvious side effects occurring. In the matched group, there happened one person having constipation for the possible reason that the function of the gastrointestinal tract in elder people went down. In the treatment group, we counterchecked the liver and the renal function after people on trial taking the medicine for 5 days, which compared with what was before the operation, showing no obvious difference. Conclusion Solifenacin succinate is an effective and safe drug for treating several symptoms (urinary urgency, urinary frequency and urge urinary incontinence) of OAB, which result from keeping catheter after the operation of transurethral electrocision of prostate. Using for a short time, this medicine didn't bring much obvious side effects, and showed no adverse effects on the function of the liver and the renal. |
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