The Development Of Methods For The Analysis Of Tetracycline Antibiotics And The Body Burdon Of Pbdes In Residents

Pollutants, especially organic ones, increased remarkably in environment with the global rapid development of economy and the increase of populations in the last decades. Global problems like water pollution, which is usually harmful to human health, have already made us realize that the water security is becoming more and more serious. Therefore it is important for the environmental protection to develope new method to detect pollutants quickly and precisely. Recently, more and more efforts have focused on the organic pollutants in China.In this paper, tetracycline antibiotics and polybrominated diphenyl ethers (PBDEs) were investigated as target pollutants:1. Developed and optimized pretreatment methods for the analysis of tetracycline antibiotics in different environmental water. Lanthanide ions was used as chelating agent to form a hydrophobic complex compound with tetracyclines, then extracted with [Bmim]PF6, an ionic liquid, followed by ultra high pressure liquid chromatography determination. Under the optimized conditions, wide linear ranges, low limits of detection (LODs) and good correlation coefficients were acquired. With our new method, we determined the levels of tetracycline antibiotics in environmental water in the area of Beijing.2. Assessed general contents and distributions of PBDEs in breast milk, maternal blood and fetal blood in the area of Taizhou, Zhejiang province. Meanwhile, we discussed whether the placenta was selectively conveying PBDEs congeners. The results showed that the mean concentration of PBDEs in maternal serum, fetal serum and breast milk was 14.05 ng/g lipid weight (lw). The level of PBDEs was higher than the range reported in Europe (5ng/glw), and much lower than those of the United States (35ng/glw).In addition, higher levels of higher brominated PBDEs exsisted in maternal serum than in fetal serum, while the lower brominated congeners were opposite. This result indicated that the higher brominated PBDEs congeners were more difficult to pass through the placenta compared to the lower brominated PBDEs congeners.In all samples, the distribution of PBDEs congeners was different in breast milk, maternal and fetal serum in Taizhou. BDE-209 was the dominant PBDE congeners in these samples. This showed that BDE-209 can accumulate in human body. The sequence of dominantΣPBDEs in all samples was:human milk> maternal serum> fetal serum.Correlation analysis showed that BDE-154 with BDE-100 and BDE-99, BDE-153 with BDE-100, BDE-99 and BDE-154, BDE-183 with BDE-153, BDE-154, BDE-100 with BDE-99, BDE-183 with BDE-100, BDE-99, BDE-153 and BDE-154, BDE-197 with BDE-100, BDE-99, BDE-153, BDE154 and BDE-183 have a strong correlation, which indicated the way that human exposure to PBDEs congeners may be similar.In summary, this study suggested that simple disassemble and recovery of electronic wastes had been causing serious pollution of PBDEs on local environment, and influenced the whole regions of Taizhou. Some measures should be taken as early as possible otherwise the consequence will be fatal.