Huoxuehuayu Method Treating The Xueyu Syndrome Of Nephrotic Syndrome

BackgroundNephrotic syndrome is a common disease of Nephrology, Nephrotic Syndrome (NS) the existence of blood hypercoagulability has been well accepted. Thrombosis is an important complication of nephrotic syndrome patients, witch can lead to acute renal failure, deep vein thrombosis, pulmonary embolism, cerebral infarction and other serious complications. Hypercoagulability also have an adverse effect for the treatment. Anticoagulant therapy is an important adjuvant treatment of NS. However, the use of anticoagulant drugs are expensive, some of the drugs require regular testing of coagulation. In the opinion of TCM, hypercoagulable state of nephrotic syndrome, are areas of Xueyu syndrome. Huoxuehuayu.MethodAlleviates Xueyu syndrome with NS, but the efficacy and the safety of Huoxuehuayu Method are lack of systematic clinical observation. Objective:This study observed Xuesaitong injection (Panax preparation) and low molecular weight heparin mitigation hypercoagulable state in nephrotic syndrome effect, attempts to Treatment Nephrotic Syndrome blood circulation effect of blood stasis syndrome, safety, cost-effective to evaluation, provide the basis for this therapy in clinical.Object and MethodsHospital Department of Nephrology, Department of our hospital 40 cases with primary nephrotic syndrome patients, randomized controlled trials using clinical methods, on the basis of conventional hormone therapy, the treatment group used Xuesaitong 0.4g IV QD, the control group with subcutaneous low molecular weight heparin 4100u IH QD, In 2 weeks. Check blood stasis points, serum albumin,24h urinary protein, platelet count, PT, APTT, INR, fibrinogen, D dimer, TC, TG, LDL, C, LP (a) and other indicators, before and after treatment. Statistical software package used SPSS13, according to data type selection test methods.ResultsThe total effective rate was 85% in the control group, the total effective rate was 80%, and the difference was not statistically significant (P> 0.05). Before and after treatment, blood stasis score,24-hour urinary protein, serum albumin, PLT, FIB, TG, CHOL, LDL decreased than before, the test was statistically significant (P<0.05 or P<0.01). BSS control group scores before and after treatment,24-hour urinary protein, serum albumin decreased, PT, APTT, INR was significantly increased, the test was statistically significant (P<0.05 or P<0.01). The treatment group than control group scores declined more obvious blood stasis, was statistically significant (P <0.05). The two groups were compared 24-hour urinary protein and albumin changes, no significant difference (P>0.05).ConclusionHuoxuehuayu Method of TCM can aid Western comprehensive treatment of NS, and patients can effectively relieve Xueyu Syndrome, regulate lipid metabolism in patients with disorders, and have higher safety and cost-effectiveness. In the course of treatment for long-term application of NS, is the treatment of hypercoagulable state in nephrotic syndrome is one effective method worthy of further research and clinical practice.