Epidemiologic Survey On The Metabolic Syndrome And Related Factors In The Community Of Luzhou

Objective:To know the metabolic syndrome (MS) prevalence of community residents over the age of 20 in Luzhou City, and to explore its risk factors and comprehensive prevention and control measures. Methods: The community residents over the age of 20 in the whole of 2010, who long stay in Luzhou old cellar group were done a cross-sectional epidemiological investigation by a random sampling method, including①Questionnaire survey: general condition, general state of health, past history of illness,family history, Smoking and drinking situation, Physical activity situation, etc;②Physical examination:body height, body weight, waistline, hip circumference,blood pressure,etc. Calculation body-mass index(BMI) and Waist hip ratio (WHR);③Laboratory tests:fasting plasma glucose (FPG),total cholesterol (TC), triglyceride (TG),high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), liver function, renal function (including uric acid), etc;④Selecting the pople who with 1-2 metabolic abnormalities indexes which met the diagnostic criteria of MS,and 30 cases of normal, routine test fasting blood glucose, ELISA assay of serum insulin (INS), free fatty acid (FFA), high sensitivity C-reactive protein (hsCRP), tumor necrosis factor a (TNF-a). The diagnostic criteria of Metabolic syndrome was made according to the Diagnostic and Statistical Manual of the Chinese Medical Association Diabetes Society (CDS) in 2004. Results:(1) Community residents over the age of 20 of LuZhou city, The BMI, waistline, WHR, systolic blood pressure(SBP), diastolic blood pressure(DBP), TG, LDL-c of Male were markedly higher than women's (P<0.01), while females' HDL-c was higher than males'. We also found that males'uric acid (UA) level higher than females'. The prevalence of community residents of MS was 10.83%,11.80% for men and 9.54% for women. The differences were significant between the sexes(P<0.01). From high to low the prealence of various components of MS was in turn for dyslipidemia, hyperglycaemia, overweight and/or obesity and hypertension.Comparison between the sexes:The male was markedly higher than women's prealence of hypertension, dyslipidemia, overweight and/or obesity(P<0.01).(2) With the growth of the age, the prevalence of metabolic syndrome rose gradually. Whether male or female, after age 50 MS prevalence increased significantly.In 60～69 prealence peaked for 22.03% and 18.72% of 57.80%.The number of metabolic abnormalities is 57.80% the total number, people with higher MS risk factors clustering.(3) The logistic regression analysis results indicated that factors were closely related to the pathogenesis of MS(P<0.05)and were the risk fastors of MS.The factors includ of gender, age, BMI, WHR, drinking,diet structure,labor or physical exercise,family history of diabetes,blood uric acid.The independent risk factors of MS were age,BMI,WHR,diet structure. While moderate exercise was the protection factor of MS.Drinking,family history of diabetes and blood uric acid were associated with MS,but not its independent risk factors (4) Of those poll, 42.19% without metabolic disturbance, with≦2 kind of metabolic abnormalities indexes is 46.97%, MS accounted for 10.83%. The age,BMI,waistline, WHR,SBP,DBP,TG,FPG,UA of MS group were significantly higher than group without metabolic disturbance or with≦2 kind of metabolic abnormalities indexes(P<.01). Group with≦2 kind of metabolic abnormalities indexes were higher than group without without metabolic disturbance (P<0.01).The HDL-c of group without metabolic disturbance were higher than group with≦2 kind of metabolic abnormalities indexes and group of MS.The difference was statistically significant(P<0.01).(5) In the selection of 90 cases,the level of FFA,TNF-a,hs-CRP of group with≦2 kind of metabolic abnormalities indexes and MS subgroup were significantly higher than subgroup without metabolic profile(P<0.01). The level of FFA,TNF-a,hs-CRP of MS subgroup were significantly higher than subgroupwith≦2 kind of metabolic abnormalities indexes (P<0.01). Conclusion:The prevalence of MS was relatively high in Luzhou old cellar group community. Its unique diet may be concerned what should cause competent unit's attention and effective intervention. To prevent MS, The main measures may be carried out actively lifestyle intervention, reducing the amount of oil and alcohol intake, strengthening physical exercise.