| Objective: Have brain lesions by summing up the optic nerve myelitis (NMO) in patients with clinical features, and with no brain lesions in patients with NMO compared, looking for identification of clinical features of significance to guide the early diagnosis.Methods: First Affiliated Hospital of Guangxi Medical University in June 2005 to June 2010 as a hospital diagnosis of NMO, and the line of the Ministry of head and spinal cord magnetic resonance imaging (MRI) examination of the patients were studied, according to the head MRI Results will be included in the study were divided into two groups, that is, the brain lesion group and the group without brain lesions. On the information included in the study two groups of patients were studied retrospectively. By comparing the two groups of epidemiology, clinical manifestations, cerebrospinal fluid characteristics, electrophysiological findings, magnetic resonance characteristics, to find clinical differences between the two groups.Results:(1) Of the NMO patients included in the study were 49 cases in which MRI examinations showed lesions in the head group of 22 patients (44.9%), 27 patients with non-lesion group (55.1%).(2) Two groups in gender (P = 0.025), age of first onset (P = 0.042), whether associated with other autoimmune diseases (P = 0.034) and so statistically significant difference was significant difference, and in the precursor Infection history (P = 0.075) no statistically significant difference in terms of significant differences; two groups of patients in the relapse rate (P = 0.029), the first attack of responsibility focus areas: optic nerve damage (P = 0.015), spinal cord injury (P = 0.043), or quickly one after another while the optic nerve and spinal cord injury (P = 0.000), whether there is other than the optic nerve and spinal cord of the central nervous system damage (P = 0.000), initial treatment of acute exacerbation of EDSS score (P = 0.026), mortality (P = 0.004) and so statistically significant difference was significant difference; compared inspections in CSF: CSF pressure (P = 0.072), CSF cell count (P = 0.064), CSF protein content (P = 0.059); in the electric Comparison of physical inspections: VEP examination (P = 0.082), BAEP examination (P = 0.075).(3) MRI examination in terms of comparison: two groups of patients in the spinal cord lesion length (P = 0.037) and whether the head of a statistically significant difference in lesion area was significant difference in patients with brain lesions, brain lesions are mostly scattered at the point Shaped or dot-like, can be distributed in the cerebral hemispheres subcortical white matter, thalamus and brain stem, the number ranging from 0.7mm to 2mm in diameter and more between the lesion border clearance, no mass effect, showed a T1 or slightly low signal Signal, T2 and FLAIR high-signal change, and no lesion enhancement, the distribution of lesions in the spinal cord with relatively long (P> 0.05) difference between the two groups were no statistically significant difference was significant.Conclusions:(1) occurs in young adults in both groups of women, but more patients with brain lesions in women, average age 45 years, compared with patients without brain lesions, late onset; patients with brain lesions associated with Other autoimmune diseases is higher than in patients without brain lesions.(2) patients with brain lesions, brain lesions than the patients without recurrence rate, showing the progress ladder, left a high degree of disability; Although both the acute or subacute onset, but the first group of patients with brain lesions Episode more performance for the optic nerve or spinal cord damage can occur in the course of the disease outside the optic nerve and spinal cord damage the central nervous system; no more brain lesions in patients simultaneously or one after another more serious damage to the optic nerve and spinal cord; patients without brain lesions Patients with brain lesions than the first attack of acute EDSS score high.(3) MRI showed brain lesions in patients with brain lesions or spots are mostly point-like shape, can be distributed in the cerebral hemispheres subcortical white matter, thalamus and brain stem, the number of ranges, and no brain, spinal cord lesion length ratio Longer lesion group. |
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