| Objective: To discuss the clinical features and experience of diagnose and treatment of children sacrococcygeal teratomas.Method: To review the clinical data of 34 cases with children sacrococcygeal teratomas retrospectively, whom were hospitalized in our hospital from January, 2001 to December, 2010.10 Male, 24 female. Age from 2days to 8 years. 19 mature, 4 immature and 11malignant type. Sex, age, pathology, clinical charater, treatment and prognosis were reviewsd respectively. Chi-square test were used as the statistical method and therewas a "statistical" difference whenαwas 0.05.Result:①Pathogenesis of malignant teratomas: The morbidity of malignant teratomas of patients aged above 1 year was higher than other patients aged below 1 year .(P<0.05, P<0.05). There is no a statistical difference of the morbidity of teratomas between different sex.②The percentage of serum AFP levels elevated in patients with malignant and immature teratomas was higher than the number in patients with mature teratoma.③29 sacrococcygeal teratomas performed excision. 21 mature(included 3 children combined individualization therapy), 4 immature and 4 malignant types were confirmed by pathematology.④18 mature teratomas performed excision. 16 immature teratomas and malignant teratomas, 5 of them combined individualization therapy;5 of them performed excision without chemotherapy,;1 of them performed excision combined chemotherapy;5 gave up treatment. 6 mature teratomas were recovered after operation, one of them with chronic sinus tract, none of them recurred. 9 immature teratomas and malignant teratomas got followed up, 4children were complete remission ,4 recurred and dead after excision, one children died of MOSF during chemotherapy treatment.Conclusion:①Children sacrococcygeal teratoma occur mainly in female.②The morbidity of malignant teratoma had connection with age, but had no connection with sex.③Serum AFP determination was valuable in differential diagnosis between benign and malignant tumors, effect observation and prognosis judgment.④Resection should be taken up as soon as possible after diagnosis. Totally resect tumor and coccyx can decrease the recrudescence of teratomas.⑤Patients with immature teratomas and malignant teratoma need combined systematic therapy. Neoadjuvant chemotherapy, resection and individualization chemotherapy after the operation can improve quality of life and increase cure rate in children with immature teratomas or malignant teratoma. |
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