Influences Of Age And Gender On Pharmacodynamics Of Cisatracurium

ObjectiveTo evaluate the influences of age and gender on pharmacodynamics of cisatracurium in patients under total intravenous anesthesia.Materials and MethodsTotal seventy-six patients undergoing selective surgery in the first affiliated hospital of Zhengzhou University from June to August 2009 were enrolled. All patients were divided into Group A and Group B according to their age. Each group was divided into two subgroups according to their gender. Group A1, nineteen male patients aged 25-59 years. Group A2, nineteen female patients aged 25-59 years. Group B1, nineteen male patients aged 65-80 years. Group B2, nineteen female patients aged 65-80 years. Neuromuscular function was assessed by train-of-four(TOF)stimulation of accelerometry and the percentage depression of the first response(T1)of the TOF stimulus was used as the study parameter. After the patient to be sedated, twitch amplitude T1 stable at 100% 5 minutes, three times of the ED95 dose of cisatracurium were given and the TOF stimulation was recorded. The onset time, maximum block duration, T125% recovery time, T190% recovery time, recovery index were recorded. SPSS 10.0 software was used for statistical analyses. Measurement data were reported as mean±SD. Groups were compared using the Student's t-test. Non-normal data were compared using rank sum test. A two tailed P-value of<0.05 was considered to be statistically significant.Results1. General Information:There were no significant differences in general information among the four groups (P>0.05) such as operation time, fluid volume and blood loss. There were significant differences in height and weight between Group Al and A2(P <0.05).2. There were no significant differences in the onset time, maximum block duration, T125% recovery time, T190% recovery time, recovery index after given three times of ED95 dose of cis-atracurium among the four groups (P> 0.05).3. The changes of hemodynamic during anesthesia:The HR, SBP, DBP, MAP of all patients were within the normal range at each time point. There were no significant differences among the four groups (P> 0.05).4. Side effectsThere were no skin flushing, blood pressure decreased, heart rate significantly increased, bronchial spasm and other release of histamine signs in the patients.ConclusionThere were no significant differences in the efficacy and recovery time when three times of the ED95 dose of cisatracurium was single injection. There was no necessary to adjust the dose of cisatracurium by the gender and age of patients.