Studies On The Fingerprint And Pharmacokinetics Of Co-Xuesaitong Dropping Pill

Co-Xuesaitong Dropping Pill is an effective preparation to cure stagnation of blood . It consists of ingredients of Fructus crataegi, Radix puerariae and Panax pseudoginseng.In this paper, we firstly established the HPLC fingerprint of Co-Xuesaitong Dropping Pill and selected 22 fingerprint peaks.All the peaks were well reproducible, special to Co-Xuesaitong Dropping Pill and they could reflect Co-Xuesaitong Dropping Pill quality. Performed by HPLC to identify the chemical constituents of the whole and individual herb of Co-Xuesaitong Dropping Pill, 5 peaks were identified.We also studied the pharmacokinetics of Rg1 and Rb1 from Co-Xuesaitong Dropping Pill in rats, and compare the pharmacokinetics of Rg1 and Rb1 after ig administration of Co-Xuesaitong Dropping Pill ,panax notoginseng saponins,panax notoginseng compatibility with kudzuvineroot and panax notoginseng compatibility with hawthom fruit .Rg1 and Rb1 that is double hump absorption is two -compar- tment model.There existed significant differences in the values of elimination AUC, Cmax and t1/2βof Rg1 , Cmax, AUC of Rb1 among Co-Xuesaitong Dropping Pill and panax notoginseng. The results showed that Rg1 and Rb1 were absorbed more quickly after administration of Co-Xuesaitong Dropping Pill than panax notoginseng. The compound compatibility of the decoction promoted the absorption of Rg1 and Rb1. It indicated that there is rationality in the compatibility of Co-Xuesaitong Dropping Pill .