| BackgroundCoronary heart disease refers to coronary artery stenosis or obstruction to blood vessels leading to myocardial ischemia and hypoxia or necrosis caused by heart disease, known coronary heart disease is atherosclerosis leading to the most common type of organ diseases. This is a serious hazard to human health. Cause of coronary atherosclerosis has not yet been fully established, its mechanism has not yet fully understood. Acute coronary syndrome includes unstable angina, non ST-segment elevation myocardial infarction and ST segment elevation myocardial infarction, the common pathological basis for the instability of atherosclerotic plaques, inflammatory response in coronary heart disease occurrence and development of play an important role have been confirmed. Ubiquitin as a small heat shock protein, may be involved in the occurrence of atherosclerosis, development, and become a research hotspot.Ubiquitin (Ub) is a 76 amino acid polypeptide highly conserved and can mediate protein degradation and NF-κB activation channels involved in cell cycle regulation, transcription regulation, apoptosis, and antigen commission involved in atherosclero-sis, chronic inflammatory pathological process. Studies have shown that high sensiti-vity C-reactive protein and TNF-a in the incidence of coronary heart disease and play an important role in the development and high sensitivity C-reactive protein and TNF-a may be involved in ubiquitin activation of NF-κB way. The serum levels of ubiquitin levels in the present study less, and high sensitivity C-reactive protein and TNF-a in coronary heart disease of less.ObjectionUbiquitin observed in the serum of patients with coronary heart disease, and to explore its clinical significance, and its relationship with high sensitive C-reactive protein and TNF-a in the relationship between coronary heart disease.MethodsMeasured in 20 patients with acute myocardial infarction (AMI),28 patients with unstable angina pectoris (UAP),25 patients with stable angina pectoris (SAP) and 15 healthy controls serum ubiquitin, tumor necrosis factor a (TNF-α), high sensitive C-reactive protein levels. And its selective coronary angiography, coronary Gensini integral calculation, analysis of their relationship, and routine testing of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), white blood cell count and other indicators, Records of past history of diabetes, hypertension and family history of coronary heart disease.Results1. Compared with healthy control group, serum ubiquitin was no significant difference in the SAP group (P>0.05), in AMI Group and UAP were significantly increased (P<0.01), UAP group and AMI group was no significant difference (P> 0.05). 2. AMI, UAP and SAP levels of serum TNF-a than the healthy control group significantly increased (P<0.01), AMI group than in UAP group (P<0.05), UAP group than in SAP group (P<0.01).3. Compared with SAP, Gensini points in the UAP group and AMI group were significantly higher (P<0.01),UAP group was no significant difference with AMI group (P> 0.05).4. Sensitive C-reactive protein levels in SAP, UAP and AMI group were elevated, And each group sensitivity C-reactive protein levels were significant differences.5. Ubiquitin, TNF-αand high sensitivity C-reactive protein concentration correlated with the Gensini scores were compared Relevance.6. Coronary heart disease patients and healthy had no statistical significance in sex, age, with comparability.Conclusions1. Ubiquitin serum and tumor necrosis factor-a, high sensitivity C-reactive protein in AMI, UAP, and SAP group were significantly higher than in healthy controls, suggesting that the three may be involved in atherosclerotic plaque development.2. Serum ubiquitin in the AMI and UAP group were significantly higher than the SAP group and the healthy control group, suggesting that ubiquitin may be involved in acute coronary events. |
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