The Study On Changes Of Serum TNF-a And Hs-CRP And Their Significance In Asthma

Objective:To study the changes and correlation of serum hs-CRP,TNF-α,total IgE and peripheral blood eosinophil counts in asthma.Methods: 34 astnmatic patients and 20 healthy adult people were selected between March in 2007 to May in 2008.Detect the levels of TNF-α,TIgE and PBEC.Results:(1)The results illustrate that the level of serum TNF-αduring the attact period pretheraphy group[(310.25±224.69)ng/L] was significantly higher than that during the post-treatment group,the difference had highly statistical significant(t=5.886,P<0.05) ;(2)The level of serum total IgE was([719.01±880.89)IU/mL], during the attack period pretheraphy group,it was obviously higher in the pretheraphy group than that in the post-group[(204.73±195.74)IU/mL] and their normal control group [(29.53±13.56) IU/mL], the difference had highly statistical (t=5.52,7.136,P<0.05),The level of serum total IgE in the post-treatment group,were still higher than those in normal control group and the difference had highly statistical significant too(t=16.01,P<0.05).The level of serum TIgE during the light midrange group was[(503.58±538.17)IU/mL]and the heavy goup was[(396.28±467.80)IU/mL] were obviously higher than that during the normal control group,the difference had highly statistical(P < 0.05),but there was no statistical between the light midrange group and the heavy group(P>0.05).(3) The level of PBEC were[(0.47±0.55)×10?/L]during the attack period pretheraphy group,It was obviously higher in the pretheraphy group than that in the post- group [(0.144±0.147)×10?/L]and their normal control group[( 0.14±0.09)×10?/L],the difference had highly statistical(t=12.31,6.641, P<0.05). The level of serum PBEC during the light midrange group was[ ( 0.52±0.64 )×10?/L]and the heavy goup was [(0.36±0.34)×10?/L] were obviously higher than that during the normal control group,the difference had highly statistical(P<0.05),but there was no statistical between the light midrange group and the heavy group(P>0.05). (4)The level of serum TNF-α(attack period pretheraphy group ) correlated positively with serum TIgE and correlated negatively correlated with FEV1% and FEV1/FVC(r=0.799,-0.693,-0.674 , P<0.05).(5)The level of serum hs-CRP was[ ( 1.62±1.14 ) mg/L] during the attack period pretheraphy group,it was obviously higher in the pretheraphy group than that in the post-treatment group([0.50±0.45)mg/L] and their normal control group[(0.49±0.17)mg/L],the difference had highly statistical significant(t=9.654,14.65,P<0.05).(6) The level of serum hs-CRP(attack period lightmidrang group )correlated positively with serum TIgE (r=0.656,P<0.05).Conclusion:1.The serum of TNF-αcan react the inflammation of asthma,conbine the TIgE,PBEC,and pulmonary function can evaculate the asthma patient's condition objectively,which is promising for future management an preven- tion and therapy of asthma.2.The findings suggest that hs-CRP might be a potential surrogate marker can react the the degree inflammation of asthma,which is promising for future management an prevention of asthma.