Effects Of GRO-1 And VEGF In The Wound Fluid Of Breast-conserving Surgery Patients By Intraoperative Radiotherapy With Electrons

Objective: To investigate the effects of growth-regulated oncogene-1(GRO-1) and vascular endothelial growth factor(VEGF) in the wound fluid of breast -conserving surgery patients by intraoperative radiotherapy with electrons during breast-conserving surgery of early breast cancer.Methods: 60 breast-conserving surgery patients were randomly divided into control group and trial group.Control group contained 30 patients who received single breast-conserving surgery.Trila group contained the renmain 30 patients who received breast-conserving surgery and ELIOT.All wound fluid was then collected.The levels of GRO-1 and VEGF in every patient were determined by ELISA.Results The levels of GRO-1 and VEGF in control group were respectively 50.08±14.09pmol/l and 427.16±20.18ng/l, and the expression of GRO-1 and VEGF was positive correlated(r=0.817,P<0.01). The levels of GRO-1 and VEGF in trial group were respectively 15.64±2.80pmol/l and 206.55±6.34ng/l., and the expression of GRO-1 and VEGF was positive correlated(r=0.449,P<0.05).Conclusion Intraoperative radiotherapy with electrons could obviously degrade the levels of GRO-1 and VEGF in the wound fluid of breast-conserving surgery patients,and the expression of GRO-1 and VEGF was positive correlated.