Study On Clinical Intervention Of Banxia Baizhu Tianma Decoction In Excessive Phlegm-dampness Type Prehypertensive Patients

ObjectiveTo study the effect of banxia baizhu tianma decoction and improved life style on the patients with excessive phlegm-dampness type prehypertension in the aspects of blood pressure, waist circumference, cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, fasting blood sugar and uric acid, which are all risk factors of cardiovascular disease, in order to find a more active and effective intervention on prehypertensive patients.MethodsA prospective, small sample and randomized control trial was applied. By using standardized clinical case report form,80 excessive phlegm-dampness type hypertensive patients were enrolled in and randomized into treatment goup, who take banxia baizhu tianma decoction everyday on the basis of an improved life style, which lasts for a month, and control group, who shift to an improved life style by diet adjust and doing moderate exercise. A 6-month following-up was carried for both groups, and the blood pressure, waist circumference, blood fat, uric acid and blood sugar were collected before the trial,2 months,4 months and 6 months after the trial respectively. A database was established and analyzed by SPSS 13.0.ResultsA comparison of inner treatment group:compared with pretherapy, the difference of blood pressure, waist circumference, blood fat, uric acid and blood sugar measured 2 months after the therapy have statistical significance. After 4 months, the parameters were getting better except blood pressure.6 months after the therapy, the indexes were marked improved, and the differences were of statistical significance. A comparison of inner control group: compared with pretherapy, the blood pressure, waist circumference, blood fat, uric acid and blood sugar measured 2 months after the therapy have slightly improved but with no statistical significance.6 months after the therapy, the indexes were marked improved, and the differences were of statistical significance except that of cholesterol. A comparison between the treatment group and control group:differences of the indexes collected 2 months after the therapy have statistical significance(p<0.05); 4 months after the therapy, the differences have statistical significance except waist circumference, high density lipoprotein and low density lipoprotein; 6 months after the therapy, only the difference of blood pressure between the two groups has statistical significance.Conclusions(1) Banxia baizhu tianma decoction combined with improved life style have an effective improvement of the blood pressure and other related risk factors for the patients with excessive phlegm-dampness type prehypertension, and the patients may benefit more from the decoction. in the aspects of blood pressure, waist circumference, cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, fasting blood sugar and uric acid, which are all risk factors of cardiovascular disease,(2) Patients with prehypertension could benefit from improved life style by reducing the blood pressure and other related risk factors, which is in coincidence with the reports of literature.(3) Banxia baizhu tianma decoction has an obvious effect in reducing blood pressure and improving the cardiovascular risk factors, but with the prolonged couse of treatment, the difference between the decoction and improved life style is becoming less and less, for the lifestyle improvement has a more obvious effect as time going. It reveals that decoction could have a faster and assured effect but may not last for a long time after the therapy ceased.