Relativity Research Of Insulin Resistance And Microalbuminuria In Type 2 Diabetes Mellitus

ObjectiveTo investigate whether insulin resistance and insulin resistance syndrome are associated with microalbuminuria in type 2 diabetes mellitus.MethodWe observed 231 patients suffering from type 2 diabetes mellitus (111 patients without hypertension,120 patients with hypertension), and they were divided into NAU group and MAU group according to whether they have microalbuminuria. We measured BMI,WHR,FPG,FINS,HbA1c,serum lipids,blood pressure and so on, evaluated the degree of insulin resistance with HOMA-IR.ResultIn all included subjects, subjects with microalbuminuria had higher BMI,WHR,SBP,DBP,prevalence of hypertension,HOMA-IR,LDL-C levels, and lower HDL-C level than subjects without microalbuminuria; In multiple regression analysis, BMI,DBP,HOMA-IR,HDL-C were found to be independent factors associated with MAU; Multiple logistic regression analysis showed that not only hypertension, but also high BMI level,HOMA-IR level and low HDL-C level were independent risk factors associated with MAU. When the normotensive subjects were analyzed separately, subjects in MAU group had higher BMI,WHR,HOMA-IR levels and lower HDL-C level than subjects in NAU group; In multiple regression analysis, BMI,FPG,FINS,HOMA-IR were independently associated with MAU; Multiple logistic regression analysis showed that BMI,FPG,FINS,HOMA-IR,HDL-C are independent factors associated with MAU.ConclusionInsulin resistance is a risk factor of microalbuminuria independent of hypertension and obesity in type 2 diabetes mellitus.