| AIMTo evaluate the dynamic changes in D-xylose absorption rate during the progression of portal hypertension to fnd a noninvasive and practical method to evaluate portal pressure.METHODSEighty male Sprague-Dawley rats, weighing 180-220 g, were randomly divided into two groups:normal control group (n= 5) and model group (n= 75). Fifty five successfully model rats were randomly divided into 11 groups (n=5). The normal control group was given normal drinking water, while the model group was given 0.03% thioacetamide (TAA) for 5 weeks and 0.04% TAA for another 5 weeks. The pathological changes in the liver and portal pressure were monitored until 6 weeks after withdrawal of TAA. The D-xylose content of the urine and portal pressure were determined at weeks 2,4,6,8,10,11,12,13,14,15, and 16, respectively. The correlation between D-xylose ab-sorption rate and portal pressure was analyzed.RESULTSAt week 8, apparent fibrous septum hyperplasia, disorganized hepatic lobule archi-tecture, and even pseudolobules were observed. Meanwhile, portal vein pressure and D-xylose absorption rate began to show signifcant changes. The D-xylose absorption rate is inversely correlated with portal vein pressure (P＜0.01). The correlation coefficient is-0.697, and the linear equation is:y=-0.01x+0.2791. CONCLUSIOND-xylose absorption rate can refect the changes in hepatic portal pressure and can be used to predict portal hypertension pressure and evaluate therapeutic effects in clinical practice. |
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