| Background:Guangxi is a high risk area of liver cancer and nasopharyngeal cancer,Early detection and early treatment of patients with high 5-year survival rate.A large number of studies have concluded that liver cancer,nasopharyngeal carcinoma screening in high-incidence area,Detection of hepatitis B surface antigen and core antibodies and EB virus antibodies as a screening indicator to determine the relevant risk groups is reliable.For people whose Hepatitis B surface antigen and core antibody were positive,a further examination of serum alpha-fetoprotein (AFP) and liver type-B ultrasonic can be taken.And the ones whose EB virus antibody (IgA/VCA) were positive,we can give further nasopharyngeal microscopic examination.For the AFP and or liver type-B ultrasonic abnormal,nasopharyngoscopy abnormal,should regularly review. Combining with other clinical examination,diagnosis and treatment can be performed as early as possible. Therefore,hepatitis B surface antigen and core antibodies are useful, in population screening and identifing high-risk populations of liver cancer,EB virus antibody tests contribute to screening and identifing high-risk populations of nasopharyngeal carcinoma.regular examination will get better results in early diagnosis for virus-positive high-risk groups who aged 30 to 59.Fellowup examination for high risk group can reduce manpower,material resources and other expenditures and may achieve better social and economic benefits.Purpose:1.To identify high-risk groups and predicting the risk of liver carcinoma and nasopharyngeal carcinama by virus serological screening in the high risk area of liver carcinoma and nasopharyngeal carcinama 2.To identify the relationship between virus infection and gender,age,which may facilitate the application of early diagnosis and early treatment of liver carcinoma and nasopharyngeal carcinoma in the future.Materials and Methods:(1)Between April and December 2009, through detecting two pairs of semi-HBV and EB virus associated antigen antibodies, 1104 patients whose hepatitis B surface antigen and core antibody were positive and 418 patients whose EB virus antibody (IgA/VCA) were positive were enrolled as guangxi high-risk population of liver carcinoma and nasopharyngeal carcinoma respectively.(2) people whose Hepatitis B surface antigen and core antibodies were positive,their peripheral blood were collected,give Liver function,AFP detection and 2 pairs semi-review,with B ultrasonic examination;for people whose EB virus antibody (IgA/VCA) were positive,can get nasopharyngoscopy;establish registration form for all positive people.(3)All patients dignosed as carcinoma would received treatment or guidance and other high risk groups would received regular follow-up.(4)Evaluate the results in the region through the cohort study among virus-positive rate,And accordingly analyze the characteristics of high-risk groups. Results:(1)we do screening in Cangwu more than half a year,The target population that meet the requirements 7711 were screened,of which 3677 were male,female 4034 people.(2)7711 out of the core of hepatitis B surface antigen positive and antibody positive at high risk of liver cancer 1104,595 males,509 females,The total positive rate of 14.32%,16.18% positive rate of men,women positive rate of 12.62%, The positive rate of men and women were significant differences in the statistical significance (P<0.05). (3) 6678 out of 7711 have test EB virus IgA/VCA antibody-positive 418 people,including 189 cases of male and female 229 cases,the total positive rate of 6.26%,5.92% positive rate of men,women positive rate is 6.57%,The positive rate of men and women were no significant differences in the statistical significance(P>0.05).(4)6678 people,hepatitis B surface antigen and IgA/VCA antibody positive while 48 people,including 25 women,23 men.Double-positive rate was 0.62%.(5)the number of surface antigen positive population in 50 to 59 age group,is smaller than 30 to 39 years old and 40 to 49 years old group (P<0.05),while there is no difference between 30 to 39 years old and 40 to 49 years old group;and surface antigen-positive population in 30 to 39 years old group the number of men is bigger than women (P<0.05),while 40 to 49 years old group and 50 to 59 age group of surface antigen-positive population the number of males and females showed no significant difference(P<0.05).the number of EB virus-positive population in 50 to 59 years group was bigger than 30 to 39 years old and 40 to 49 years old group (P<0.05),while the number of EB virus-positive population was no significant difference between 30 to 39 years old and 40 to 49 years old group (P＜0.05),30 to 39 years old group of EB virus-positive population in the number of women is bigger than men (P<0.05),while 40 to 49 years old group and the 50 to 59-year-old group EB virus-positive population the number of males and females the difference was not statistically significant (P<0.05).(6)the number of the people with virus positive who go to redetect is 691, Detection of abnormal liver function 63, including 19 males,44 females, Detected in 26 AFP-positive,the positive rate was 3.76%, And 9 cases were diagnosed nasopharyngeal carcinoma,B ultrasonic examination of 84 cases of liver abnormalities.both detection of abnormal liver function and B ultrasonic examination of liver abnormalities of 14.Conclusions:in Cangwu screening at age population,the positive rate of HBV infection is 14.32%,there is a statistically significant association between Hepatitis B infection and sex and age,Aged 30 to 50-year-old relatively higher risk of infection,and the risk of infection is higher in men than in women. The positive rate of EB virus infection is 6.26%,and EB virus infection risk in people aged 50 to 59-year-old is higher than others,EB virus infection has no statistical significant differences in gender.These results validate previous studies,this will provide realistic basis for future early detection and treatment of liver cancer and NPC. |
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