Addition Of Hepatectomy For Hilar Cholangiocarcinoma

Objective To evaluate the clinical efficacy of resection with hepatectomy in treat- ment of hilar cholangiocarcinoma and the prognostic factors for surviva.Methods The clinical and follow-up data of 64 patients with hilar cholangiocarcinoma who under- went resection in Union Hospital of Fujian Medical University from January 1996 to June 2009 were analyzed retrospectively. Results Sixty-four patients underwent laparotomy for tumor resection with (hepatectomy group,n=41)or without partial hepatectomy(non-hepatectomy group,n=23) .Of 33 patients submitted radical operation, hepatectomy were performed in 25 patients(60.98%), non-hepatectomy in 8 patients (34.78%) ,they show statistically significant difference(P=0.044).The 1-year,3-year survival rate of the hepatectomy group was 82.6%,32.1%respectively,which was significant greater than 56.2%, 17.3% of the non-hepatectomy group ( P=0.01) . No statistically significant difference between the two groups of the complications (P=0.949%).Univariate analysis showed addition of hepatectomy, radical operation, vascular invasion,lymph node metastasis and nerve invasion as poor prognostic predictors contributing survivals.Multivarite analysis revealed addition of hepatectomy, vascular invasion,lymph node metastasis and nerve invasion as an independent prognostic factor affecting survival. Conclusions Addition of hepatectomy is a important measure to improve the radical resection rate and survical for patients with hilar cholangiocarcinoma, the vascular invasion,lymph node metastasis and nerve invasion impact the prognosis.