The Relationship Between Hepatocellular Carcinoma Matastasis/Recurrence And The Expression Of GLUT1/P21^RAS

Objective:Primary liver cancer occurrence,development involving many genes,molecular level changes,Malignant high, vulnerable to invasion,5-year survival rate is very low. Now, it concluded,GLUT1 in primary liver cancer recurrence of metastases positively, it provides cancer cell proliferation need energy supply,and with the development of tumor cells that gradually enhanced overexpression.RAS gene expression in a protein-protein,P21ras It not only by intracellular signal transduction pathway cell growth and transformation,invasion and metastasis,and other characteristics, P21 protein is also a kind of GTP-binding protein,The GTP molecule in glucose into energy substances-ATP process,has an important role.So P21ras protein and GLUT1, there are important linkages.But the GLUT1 and P21ras in liver cancer metastasis of research on the relationship between report yet.In this experiment, We study the expression of GLUT1 and P21ras in hepatocellular carcinoma,whether they could be used as a prognostic indicators in patients with tumor matastasis and recurrence.The main reason is the liver cancer forming thrombi portal easily cause liver spread.Methods:45 cases is collected in the fist affiliated hospital of Dalian medical university during 2003-2008 which to do the research.By the means of immuno-histochemical S-P methed,we try to find out the espression of GLUT1 and P21 in 45 cases with human hepatocellular carcinoma.Results:1.GLUT1 in expression of liver cancer rate of 72.3%(33/45).The expression of GLUT1 in hepatocellular carcinoma was related to the tumor size,histological grade,distant metastasis,lymph node metastsis,portal vein tumor thrombus,and the recurrence of time-related(P<0.05).2. P21ras in expression of liver cancer rate of 91.2%(41/45).The expression of GLUT1 in hepatocellular carcinoma was related to the tumor size,histological grade,distant metastasis,lymph node metastsis,portal vein tumor thrombus,and the recurrence of time-related(P<0.05).3. With the increase expression of GLUT1, the expression of P21 was increased; positive correlation was found between GLUT1 and P21 expression (P<0.05).Conclusions:1.In primary hepatocellular carcinoma,There is a clear relationship between overexpression of GLUT1 and the occurrence of primary liver cancer,development and prognosis.And so do P21ras2.The expression of GLUT1and P21ras significantly correlated,suggesting that overexpression of P21ras protein to some extent contributed to hepatocellular carcinoma metastasis.3.The expression of GLUT1 and invasion and metastasis of liver cancer closely associated,both positive forecast the metastasis of HCC has a certain significance.