| ObjectiveThis randomized controlled study observes the clinical curative effect and safety of back-shu and front-mu combination application therapy to treat bronchial asthma.Methods100 subjects of bronchial asthma were selected who have been treated in Wang Yungu's Chinese Medicine Clinic in Taiwan from June 2009 to January 2010 and who have met the Western Medicine inclusion and exclusion criteria. The qualified subjects were randomly classified into the Treatment Group and the Controlled Group (Electric Needle Group) at the rate of 1:1 with 50 in each group. The Treatment Group adopts back-shu and front-mu combination application therapy and the Controlled Group adopts electric needle therapy. The acupoints selected in the Treatment Group:Shu-acupoint:Lung Shu, Spleen Shu, Kidney Shu and the corresponding mu-acupoints:Zhongfu, Zhangmen and Jingmen. Conduct point application for 8 hours to the subjects'tolerance and apply 3 times in a treatment course. At the focal scorching hot and itching, take off the application. Chinese Medicine constituents:Musk, DryobalanopsaromaticaGwaertn.f, rhizome corydalis, Pheretimaas pergilum, Pinellia Tuber, rhizome arisaematis, Manchurian Wildgingerand, Semen Brassicae and Euphorbia kansui. Grind and adjust with fresh ginger and make into pills with 3 g each. Stick to a point and fix with sticking plaster. Controlled Group:apply electric needle to the same acupoints with the Treatment Group. After qi is achieved, connect the needles with electric needle device with frequency of 80 HZ and maintain for 40 minutes. Treat 5 days every week and 4 weeks make a treatment course. After 1 treatment course in two groups, observe the major symptoms and body signs of asthma. The scoring of symptoms and body signs refers to the rating criteria of asthma symptoms in Guidelines for Chinese Medicine New Drug Clinical Research. Lung function examination includes 1-second FEVI, PEF and safety indexes. Measure the above indexes before and after treatment. At the end of the treatment course, evaluate clinical curative effect and safety.Data processing:Collect clinical material in time at the end of the clinical research. Use software EPIDATA 3.01 to set up the database for data management. Statistics:for classified material, takeχ2 test; for ranked material, take Wilcoxon rank sum test; for the average comparison of the two samples, take t test or Wilcoxon rank sum test; for the self circa test, take pair t test or pair Wilcoxon rank sum test. Use software SPSS 17.0 for statistics and analysis. Draw the statistics graphs with software Graph Pad Prism 4.03.Result1. In the Treatment Group, the clinical control rate is 6.0%, the excellence rate is 16.0%, the effective power is 66.0%, the clinical control excellence rate is 22.0%, and the total effective power is 88.0%; those of the Controlled Group are 0%,10.0%,60.0%,10% and 70%. Compare the curative effect of the two groups and the author finds that the clinical control excellence rate the total effective power are significantly higher than those of the Controlled Group (P=0.01).2. The total score of Chinese Medicine syndromes of the Treatment Group is lower than that of the Controlled Group and the difference has statistical significance (P<0.01).3. Single symptom's curative effect:In the Treatment Group, the remission rate of gasping, liability to catch a cold, and nasal obstruction and discharge are 84.0%,87.5%,82.6% respectively. Thos e of the Controlled Group are 52.0%,56.5%,62.5% respectively. It can be confirmed that the Treatment Group is superior to the Controlled Group in curative effect. The difference has statistical significance (P<0.05). Times of gasping:30 (60.0%) in the Treatment Group while 22 (44.0%) in the Controlled Group have improved at level 2 or above. The difference has statistical significance (P<0.05).There's no statistical significance (P>0.05) in the remission of stethocatharsis, chest upset, lumbar and knee debility, cough, throat itching, aversion to wind and wheezing. 4. The FEV1 and PEFC of lung ability of the two groups rise. Compared with those before treatment, the difference has statistical significance (P<0.01). The variance of FEV1 and PEFC of the Treatment Group before and after treatment is larger than that of the Controlled Group, but the statistical shows there's no significance (P>0.05). It indicates that the two groups have no obvious effect on lung function and doesn't form proportion with the improvement of clinical symptoms.Safety examination:Check blood, stool and urine routine tests, GPT, BUN before treatment. The recheck after treatment finds no abnormality.No adverse reactions or symptoms are observed during treatment.ConclusionApplying back-shu and fron-mu acupoints application in dog days can significantly improve the symptoms of bronchial asthma, reduce the occurrence and has safe and reliable effect, therefore it can prevent and treat the disease. |
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