Clinical And Experimental Research Of Yiqirunchang Decoction On Treating The Middle-aged And Elderly Patients With Functional Constipation

Objective:Through observation and comparison of middle-aged and elderly functional constipation treatment group and comparison group, the different clinical efficacy and relapse rates in different groups were compared, investigating traditional Chinese medicine treatment of functional constipation in middle-aged and elderly efficacy and reducing treatment recurrence of problems on the edge. And conducting animal studies to further explore the mechanism of yiqirunchang decoction treatment of constipation.Methods:Clinical studies:we used prospective randomized controlled trial design. 70 cases of functional constipation in middle-aged and elderly patients were included in this clinical study, in which 4 patients of treatment group fell and 5 cases of control group fell, so 31 patients in treatment group and 30 patients in the control group. The treatment group's program was 4 weeks of oral yiqirunchang decoction; the control group's was oraling Mosapride citrate dispersible tablet plus Polygluosan Capsules for 4 weeks. Then, we compared the efficient of the two groups after treated 2 weeks and 4 weeks and compared the recurrence rate of withdrawal 4 weeks and 8 weeks.Animal studies:we used randomized controlled trial design, taking 132 male and female NIH mice into the animal experiment, in which the Dehydration constipation group has 48 mice, the normal group had 36 mice, and the atropine load group had 48 mice.2 cases in atropine load group because of operational errors, they were not included in statistics. Dehydration constipation group were observed the first defecation time, the number of stool grains, the number of black stool grains and quantity 8 hours after taking. The other two groups were observed change of the rate of small intestine advance 15 minutes after taking.Results:The clinical results showed that:traditional Chinese medicine treatment group and control group on the Treatment of functional constipation had good effect,2 weeks and 4 weeks after in the traditional Chinese medicine treatment group the total effective rate were 80.6% and 87.1%; of western medicine group were 83.3% and 80.0%, treatment of two groups for 2 weeks total effective rate had no significant difference (P>0.05); Treatment of 4 weeks, the total efficiency of the two groups had significant difference (P<0.05); and Chinese medicine treatment group,, the total effective rate of 2 weeks and 4 weeks had significant difference (P<0.05), while control group, the total effective rate of 2 weeks and 4 weeks, had no significant difference (P>0.05). In reducing the relapse rate after treatment on the traditional Chinese medicine group was significantly better than the control group. Withdrawed for 4 weeks and 8 weeks after the total recurrence rate of the traditional Chinese medicine group were 18.5% and 33.3%, western medicine group were 41.7% and 58.3%, recurrence rate between the two groups had significantly different (P<0.05).Animal experiments results showed that:for the dehydration constipation group, in the large doses and small doses of yiqirunchang decoction groups the time when the mice first defecated dark stool was obviously reduced, and the number of stool grains and quantity were obviously increased, compared with the model group, there were significant difference (P<0.05); for the normal group, the large doses and small doses of yiqirunchang decoction groups could speed up the rate of small intestinal advance, compared with the control group, there were significant differences (P<0.05); for the atropine load group, adding atropine load could reduce the rate of small intestinal advance, the percentage in the large doses and small doses of yiqirunchang decoction groups were increased, compared with the model group, there were significantly different (P<0.05). However, in the three groups, the influence of the large doses and small doses of yiqirunchang decoction groups was no significant difference (P>0.05).Conclusion:The clinical observation showed that:Chinese medicine treatment group and comparison group, to treat the middle-aged and elderly patients with functional constipation, had a good effect. The treatment of yiqirunchang decoction 2 weeks after, compared with Mosapride citrate dispersible tablet plus Polygluosan Capsules, there had no significant difference. As the time of treatment, Chinese medicine group increased efficiency, while the control group hadn't. The efficiency of treatment group was significantly higher than the control group after 8 weeks. In reducing the relapse rate after stopping on, the yiqirunchang decoction was better than Mosapride citrate dispersible tablet plus Polygluosan Capsules. And during treatment, the yiqirunchang decoction group had no significant adverse reactions.Animal experiments showed that:the large doses and small doses of yiqirunchang decoction could obviously reduce the time when the mice first defecated dark stool, and increase the number of stool grains and quantity. They could also increase the rate of small intestinal advance in normal mice, and had a good antagonism against the inhibition of atropine to intestinal advance, thus enhancing the defecation function. But the effect between the two groups showed no significant difference.