The Effection Of High-flux Hemodialysis To Survival And Recovery Rate Of The Patients With Acute Renal Failure

ObjectiveConsiderable controversy exists as to whether the high-flux membranes improve prognosis and survival in patients with acute renal failure compared to low-flux types. Although the discordant results of existing studies could be explained by the varying degrees of different membranes used, the statistical power is low. So we combining the results from all published trials would provide a better estimate of the effects of membranes composition on survival in acute renal failure.MethodsWe performed a meta-analysis of all previously published prespective trials comparing the use of high-flux with low-flux membranes for hemodialysis in patients with ARF.ResultsThe cumulative odds ratio(OR) for survival in favor of high-flux membranes was 1.56 (95%CI 1.15 to 2.13, P=0.005). And for renal recovery is 1.22, (95%CI 0.48 to 3.09, P=0.67).ConclusionsHigh-flux dialytic membranes appear to confer a significant survival advantage over low-flux types. We could not demonstrate a similar benefit with use of high-flux membranes over low-flux types for recovery of renal function for the sample size was limited.