The Application And Value Of Measuring Serum CA72-4, CA19-9, CEA Standard In Cure Of Gastric Carcinoma

Gastric cancer is the world's second highest incidence of malignant tumors, but also common malignancy in our country, the mortality rate ranks first in China, about 17 million people died of stomach cancer each year, almost all cancer deaths close to 1/4, and each year there are more than 20,000 new cancer patients have come out, How can the diagnosis of early treatment in order to take radical measures to achieve a good prognosis for its the only way .Although early screening test for gastric cancer has formed a preliminary specification, but the detection rate is always less than satisfactory, the overall 5-year survival rate is only about 30%. The common causes of poor prognosis is the patients with gastric cancer was advanced gastric cancer when founded and it is can not radical surgery, but the most important thing is cancer metastasis and recurrence after treatment. Tumor marker is the tumor tissue and cancer cells as abnormal expression of genes and their products produced by antigen and biological active substances, such substances in the normal tissue and benign lesions does not produce or produce very little, which reflects the tumor occurred during the change of genes. Search for tumor-specific antigen in cancer research has been hot, serum tumor markers in the early days by people from the discovery of high expectations, hoping it would in cancer diagnosis and treatment play an important role.CA19-9 exist in the pancreas, bile duct, stomach, intestine, endometrium, salivary gland epithelium on. Also known as gastrointestinal cancer associated antigen is a substance with cancer-related antigens from cancer cells by thoracic duct drainage to the blood circulation, causing increased peripheral blood CA19-9 levels, the highest content in the digestive tract. CA19-9 increased significantly better than the other tumor markers when the patients of gastric cancer with pancreatic metastasis and liver metastasis. CA72-4 were present in 85% to 95% of the stomach, colon, pancreas, lung and ovarian tumors, does not exist in benign or normal tissue exudates, or expression in non-epithelial tumor cells, including melanoma tumor, sarcoma, spinal tumors, leukemia and lymphoma, a very low level of expression in some malignant mesothelioma, about 6.7% of gastrointestinal tract disease, 40% of gastrointestinal cancers, 36% of lung cancer, 24% of patients of ovarian cancer can be increased. CA72-4 is a high molecular weight class of glycoproteins, is the intestinal tract, and ovarian tumor marker . In terms of primary gastric cancer is more valuable than CEA and CA19-9 can be used as a reference and staging of gastric cancer recurrence after treatment basis. CA72-4 is a reliable diagnostic marker for gastric cancer. CA72-4 is a reliable diagnostic marker for gastric cancer, the sensitivity of gastric cancer 59% ~ 94%, specificity 95% to 100%.The diagnosis of gastric cancer reported in the literature CA72-4, with the progression of gastric cancer, CA72-4 positive rates of different,â… ,â…¡gastric cancer, CA72-4 positive rate was 7.1%~95%,â…¢,â…£of 29% to 100% of recurrent CA72-4- positive rate of gastric cancer 60%~90%, whileâ… ,â…¡gastric cancer among non-cancer group,â…¢,â…£gastric cancer difference between the serum CA72-4 levels were significantly (P<0.01). That also reflects the level of CA72-4 tumor invasion and metastasis. CEA is the most specific one of carcinoembryonic protein molecular weight 22ku polysaccharide protein complex, the human digestive system is an acidic cell surface glycoprotein to the cell surface to the rectum, followed by stomach, esophagus. The gene is located on the long arm of human chromosome 19 present in fetal intestine and differentiation from the endoderm to the tumor cell membrane. Gastric cancer, liver cancer, lung cancer, colon cancer Dengjun increased. CEA is a broad spectrum of tumor markers, genetic immunoglobulin superfamily is a member, is also a class of cell adhesion molecules, and then regulate the interaction between cells play a role in the cell and then knowledge. CEA is the most widely used clinical tumor marker, one of the relative maturity of various aspects of research.The study of 119 patients, of which 81 cases of gastric cancer patients, 23 patients with benign gastric disease, and control group 15 cases. CA19-9 kit, CA72-4 kit and CEA kit all with Roche Inc. Detect the level of CA-199, CA72-4, CEA. Evaluate the diagnostic value of gastric cancer by ROC curve and discriminant analysis , Draw a comparison about the combined with three kinds of lines and TM alone, Investigate application method of tumor markers (TM), and by analyzing the influence of serum tumor markers (TM) level factors and pathological findings in patients with gastric cancer link, On the test results were analyzed statistically.Explore in the treatment of gastric cancer and prognosis application.This study shows that: gastric cancer serum CA19-9, CA72-4, CEA positive rates were 83.95%, 85.19%, 87.65% higher than other control group, benign gastric group. These findings suggest that CA-199, CA72-4 and CEA diagnosis of gastric cancer ROC area under the curve were 0.901,0.941 and 0.942. CA19-9, CA72-4 and CEA accuracy of diagnosis of gastric cancer were 81.51%, 84.03% and 89.08%. Serum CA19-9, CA72-4 and CEA levels in gastric cancer associated with the pathology. Serum CA19-9, CA72-4 and CEA levels associated with clinical stage of gastric cancer. CA19-9, CA72-4 and the combined detection of CEA is a reliable indicator of diagnosis of gastric cancer, with high sensitivity and specificity.